RESEARCH

Other systems & functions

Gynecomastia

Find case reports on PubMed

Ferrando J, Grimalt R, Alsina M, Bulla F, Manasievska E. Unilateral gynecomastia induced by treatment with 1 mg of oral finasteride. Arch Dermatol. 2002;138(4):543‐544. doi:10.1001/archderm.138.4.543 | PubMed

Green L, Wysowski DK, Fourcroy JL. Gynecomastia and breast cancer during finasteride therapy. N Engl J Med. 1996 Sep 12;335(11):823. doi:10.1056/NEJM199609123351116 | PubMed

Hagberg KW, Divan HA, Fang SC, Nickel JC, Jick SS. Risk of gynecomastia and breast cancer associated with the use of 5-alpha reductase inhibitors for benign prostatic hyperplasia. Clin Epidemiol. 2017;9:83‐91. doi:10.2147/CLEP.S124674 | PubMed

Lee SG, Park PJ, Lee SR, et al. Influence of postoperative finasteride therapy on recurrence of gynecomastia after mastectomy in men taking finasteride for alopecia. Am J Mens Health. 2019 Sep-Oct;13(5):1557988319871423. doi:10.1177/1557988319871423 | PubMed

Ramot Y, Czarnowicki T, Zlotogorski A. Finasteride induced gynecomastia: case report and review of the literature. Int J Trichology. 2009;1(1):27–29. doi:10.4103/0974-7753.51930 | PubMed

Schmutz JL, Barbaud A, Trechot P. Gynécomastie et finastéride (Propecia): 4 nouveaux cas [Gynecomastia and finasteride (Propecia): 4 new cases]. Ann Dermatol Venereol. 2004 Jun-Jul;131(6-7 Pt 1):615. French. doi:10.1016/s0151-9638(04)93684-8 | PubMed

Sleep

Gupta MA, Vujcic B, Sheridan AD, Gupta AK. 0917 Finasteride is associated with a higher odds of obstructive sleep apnea (OSA): results from the US FDA Adverse Events Reporting System (FAERS). Sleep. 2018 Apr;41(Suppl 1). doi:10.1093/sleep/zsy061.916

Musculoskeletal

Al-Harbi TM, Kagan J, Tarnopolsky MA. Finasteride-induced myalgia and HyperCKemia. J Clin Neuromuscul Dis. 2008 Dec;10(2):76-8. doi:10.1097/CND.0b013e3181873ccaPubMed

[⚠️ GlaxoSmithKline-funded] Amory JK, Anawalt BD, Matsumoto AM, et al. The effect of 5alpha-reductase inhibition with dutasteride and finasteride on bone mineral density, serum lipoproteins, hemoglobin, prostate specific antigen and sexual function in healthy young men. J Urol. 2008;179(6):2333-2338. doi:10.1016/j.juro.2008.01.145 | PubMed

Antoniou T, Macdonald EM, Yao Z, et al. A population-based study of the risk of osteoporosis and fracture with dutasteride and finasteride. BMC Musculoskelet Disord. 2018;19(1):160. doi:10.1186/s12891-018-2076-9 • PubMed

Borst SE, Yarrow JF, Conover CF, et al. Musculoskeletal and prostate effects of combined testosterone and finasteride administration in older hypogonadal men: a randomized, controlled trial. Am J Physiol Endocrinol Metab. 2014 Feb 15. doi:10.1152/ajpendo.00592.2013 • PubMed • PMC full text

Haan J, Hollander JM, van Duinen SG, Saxena PR, Wintzen AR. Reversible severe myopathy during treatment with finasteride. Muscle Nerve. 1997 Apr;20(4):502-4. doi:10.1002/(SICI)1097-4598(199704)20:4%3C502::AID-MUS15%3E3.0.CO;2-%23PubMed

Matsumoto AM, Tenover L, McClung M, et al; Pless Study Group. The long-term effect of specific type II 5alpha-reductase inhibition with finasteride on bone mineral density in men: results of a 4-year placebo controlled trial. J Urol. 2002 May;167(5):2105-8. PubMed

Ryu HJ, Kwon DY. Reversible myopathy and ophthalmoparesis after low-dose finasteride administration for androgenic alopecia. Dermatol Surg. 2014;40(5):595-597. doi:10.1111/dsu.12458 • PubMed

DNA damage & effects

See also: Research by field: Genetics & epigenetics and Special topics: DNA repair

Albasher G, Bin-Jumah M, Alfarraj S, et al. Prolonged use of finasteride-induced gonadal sex steroids alterations, DNA damage and menstrual bleeding in women. Biosci Rep. 2020. doi:10.1042/BSR20191434 • PubMed • PMC full text

Alkahtane AA, Albasher G, Al-Sultan NK, et al. Long-term treatment with finasteride induces apoptosis and pathological changes in female mice. Hum Exp Toxicol. 2019. doi:10.1177/0960327119842195 • PubMed

Angrimani DSR, Bicudo LC, Llamas Luceño N, et al. Does finasteride treatment for benign prostatic hyperplasia influence sperm DNA integrity in dogs? Basic Clin Androl. 2020. doi:10.1186/s12610-020-00108-2 • PubMed

Rittmaster RS, Magor KE, Manning AP, Norman RW, Lazier CB. Differential effect of 5 alpha-reductase inhibition and castration on androgen-regulated gene expression in rat prostate. Mol Endocrinol. 1991. doi:10.1210/mend-5-7-1023 | PubMed

Tu HY, Zini A. Finasteride-induced secondary infertility associated with sperm DNA damage. Fertil Steril. 2011. doi:10.1016/j.fertnstert.2010.12.061 • PubMed

Photosensitivity

Espasandín-Arias M, García-Rodiño S, Suárez-Peñaranda JM, Rodríguez-Granados MT. Photosensitivity associated with dutasteride therapy. J Dtsch Dermatol Ges. 2020 Apr. doi:10.1111/ddg.14062 • PubMed

Santo Domingo D, Stevenson ML, Auerbach J, Lerman J. Finasteride-induced pseudoporphyria. Arch Dermatol. 2011. doi:10.1001/archdermatol.2011.144 • PubMed

Yamada T. Photosensitivity reaction induced by finasteride. J Gen Fam Med. 2021 Nov 5. doi:10.1002/jgf2.510 • PubMed • PMC full text