Bibliography: Persistent adverse effects & ‘post-finasteride syndrome’

See also: Full bibliography on adverse effects of finasteride and Systematic reviews and meta-analyses.


Ali AK, Heran BS, Etminan M. Persistent Sexual Dysfunction and Suicidal Ideation in Young Men Treated with Low-Dose Finasteride: A Pharmacovigilance Study. Pharmacotherapy. 2015;35(7):687-695. doi:10.1002/phar.1612 | PubMed

Basaria S, Jasuja R, Huang G, et al. Characteristics of Men Who Report Persistent Sexual Symptoms After Finasteride Use for Hair Loss. J Clin Endocrinol Metab. 2016;101(12):4669-4680. doi:10.1210/jc.2016-2726 | PubMed

Borgo F, Macandog AD, Diviccaro S, Falvo E, Giatti S, Cavaletti G, Melcangi RC. Alterations of gut microbiota composition in post-finasteride patients: a pilot study. J Endocrinol Invest. 2020 Sep 19. doi:10.1007/s40618-020-01424-0 | PubMed

Di Loreto C, La Marra F, Mazzon G, Belgrano E, Trombetta C, Cauci S. Immunohistochemical evaluation of androgen receptor and nerve structure density in human prepuce from patients with persistent sexual side effects after finasteride use for androgenetic alopecia. PLoS One. 2014;9(6):e100237. doi:10.1371/journal.pone.0100237 | PubMed

Diviccaro S, Melcangi RC, Giatti S. Post-finasteride syndrome: An emerging clinical problem. Neurobiol Stress. 2019;12:100209. doi:10.1016/j.ynstr.2019.100209 | PubMed

Fiuk, J., Butcher, M., Kohler, T., & McVary, K. (2016). 133 Female Post-Finasteride Syndrome: It’s Not Just A Man’s World. Journal Sex Med, S62-S63. doi:10.1016/j.jsxm.2016.02.139

Ganzer CA, Jacobs AR, Iqbal F. Persistent sexual, emotional, and cognitive impairment post-finasteride: a survey of men reporting symptoms. Am J Mens Health. 2015;9(3):222-228. doi:10.1177/1557988314538445 | PubMed

Garreton, A. S., Valzacchi, G. R., & Layus, O. Post-Finasteride Syndrome: About 2 Cases and Review of the Literature. Andrology-Open Access. 2016;5(2):170. doi:10.4172/2472-1212.1000170 | Journal site

Giatti S, Diviccaro S, Panzica G, Melcangi RC. Post-finasteride syndrome and post-SSRI sexual dysfunction: two sides of the same coin? Endocrine. 2018;61(2):180-193. doi:10.1007/s12020-018-1593-5 | PubMed

Goldstein I. An old problem with a new cause-5 alpha reductase inhibitors and persistent sexual dysfunction. J Sex Med. 2011;8(7):1829–1831. doi:10.1111/j.1743-6109.2011.02368.x | PubMed

Gray SL, Semla TP. Post-finasteride syndrome. BMJ. 2019;366:l5047. doi:10.1136/bmj.l5047 | PubMed

Guo M, Heran B, Flannigan R, Kezouh A, Etminan M. Persistent Sexual Dysfunction with Finasteride 1 mg Taken for Hair Loss. Pharmacotherapy. 2016;36(11):1180-1184. doi:10.1002/phar.1837 | PubMed

Gupta AK, Sharma N, Shukla P. Atypical post-finasteride syndrome: A pharmacological riddle. Indian J Pharmacol. 2016;48(3):316–317. doi:10.4103/0253-7613.182898 | PubMed

Healy D, Le Noury J, Mangin D. Enduring sexual dysfunction after treatment with antidepressants, 5α-reductase inhibitors and isotretinoin: 300 cases. Int J Risk Saf Med. 2018;29(3-4):125-134. doi:10.3233/JRS-180744 | PubMed

Irwig MS. Androgen levels and semen parameters among former users of finasteride with persistent sexual adverse effects. JAMA Dermatol. 2014;150(12):1361-1363. doi:10.1001/jamadermatol.2014.1830 | PubMed

Irwig MS. Persistent Sexual and Nonsexual Adverse Effects of Finasteride in Younger Men. Sex Med Rev. 2014;2(1):24-35. doi:10.1002/smrj.19 | PubMed

Irwig MS. Persistent sexual side effects of finasteride: could they be permanent? J Sex Med. 2012 Nov;9(11):2927-32. doi:10.1111/j.1743-6109.2012.02846.x | PubMed

Irwig MS, Kolukula S. Persistent sexual side effects of finasteride for male pattern hair loss. J Sex Med. 2011;8(6):1747-1753. doi:10.1111/j.1743-6109.2011.02255.x | PubMed

Khera M, Than JK, Anaissie J, et al. Penile vascular abnormalities in young men with persistent side effects after finasteride use for the treatment of androgenic alopecia. Transl Androl Urol. 2020;9(3):1201-1209. doi:10.21037/tau.2020.03.21 | PubMed

Kiguradze T, Temps WH, Yarnold PR, Cashy J, Brannigan RE, Nardone B, Micali G, West DP, Belknap SM. Persistent erectile dysfunction in men exposed to the 5α-reductase inhibitors, finasteride, or dutasteride. PeerJ. 2017;5:e3020. doi:10.7717/peerj.3020 | PubMed

Kuhl, H., Wiegratz, I. Das Post-Finasterid-Syndrom. Gynäkologische Endokrinologie. 2017;15:153–163. doi:10.1007/s10304-017-0126-2

Maksym RB, Kajdy A, Rabijewski M. Post-finasteride syndrome – does it really exist? Aging Male. 2019;22(4):250–259. doi:10.1080/13685538.2018.1548589 | PubMed

Melcangi RC, Caruso D, Abbiati F, et al. Neuroactive steroid levels are modified in cerebrospinal fluid and plasma of post-finasteride patients showing persistent sexual side effects and anxious/depressive symptomatology. J Sex Med. 2013;10(10):2598-2603. doi:10.1111/jsm.12269 | PubMed

Melcangi RC, Santi D, Spezzano R, et al. Neuroactive steroid levels and psychiatric and andrological features in post-finasteride patients. J Steroid Biochem Mol Biol. 2017;171:229-235. doi:10.1016/j.jsbmb.2017.04.003 | PubMed

Mervis JS, Borda LJ, Miteva M. “Post-finasteride syndrome”: what to tell our female patients? Br J Dermatol. 2018;179(3):785-786. doi:10.1111/bjd.16658 | PubMed

Motofei IG, Rowland DL, Georgescu SR, et al. Post-Finasteride Adverse Effects in Male Androgenic Alopecia: A Case Report of Vitiligo. Skin Pharmacol Physiol. 2017;30(1):42-45. doi:10.1159/000455972 | PubMed

Pereira AFJR, Coelho TOA. Post-finasteride syndrome. Anais Brasileiros de Dermatologia. 25 March 2020. doi:10.1016/j.abd.2020.02.001 | PubMed

Rezende HD, Dias MFRG, Trüeb RM. A Comment on the Post-Finasteride Syndrome. Int J Trichology. 2018;10(6):255-261. doi:10.4103/ijt.ijt_61_18 | PubMedFree PMC Article

Rivera Mirabal J, Than J, Annaisie J, Antar A, Song W, Losso B, Pastuszak A, Kohn T, Khera M. 124 The persistent effects of 5α-reductase inhibitors used in the treatment of androgenic alopecia on men’s health. J Sex Med.2020;17(1):S33–S34. doi:10.1016/j.jsxm.2019.11.070

Singh MK, Avram M. Persistent sexual dysfunction and depression in finasteride users for male pattern hair loss: a serious concern or red herring? J Clin Aesthet Dermatol. 2014;7(12):51-55. PubMed

Sung HH, Yu J, Kang SJ, et al. Persistent Erectile Dysfunction after Discontinuation of 5-Alpha Reductase Inhibitor Therapy in Rats Depending on the Duration of Treatment. World J Mens Health. 2019;37(2):240–248. doi:10.5534/wjmh.180082 | PubMed

Than JK, Rodriguez K, Khera M. Post-finasteride Syndrome: A Review of Current Literature. Curr Sex Health Rep.2018;10:152-157. doi:10.1007/s11930-018-0163-4

Traish AM. Post-finasteride syndrome: a surmountable challenge for clinicians. Fertil Steril. 2020;113(1):21-50. doi:10.1016/j.fertnstert.2019.11.030 | PubMed

Traish AM, Hassani J, Guay AT, Zitzmann M, Hansen ML. Adverse side effects of 5α-reductase inhibitors therapy: persistent diminished libido and erectile dysfunction and depression in a subset of patients. J Sex Med. 2011;8(3):872-884. doi:10.1111/j.1743-6109.2010.02157.x | PubMed

Trüeb RM, Régnier A, Dutra Rezende H, Gavazzoni Dias MFR. Post-Finasteride Syndrome: An Induced Delusional Disorder with the Potential of a Mass Psychogenic Illness? Skin Appendage Disord. 2019;5(5):320-326. doi:10.1159/000497362 | PubMed

Walf AA, Kaurejo S, Frye CA. Research Brief: Self-Reports of a Constellation of Persistent Antiandrogenic, Estrogenic, Physical, and Psychological Effects of Finasteride Usage Among Men. Am J Mens Health. 2018;12(4):900-906. doi:10.1177/1557988317750989 | PubMed

Animal study

Oztekin CV, Gur S, Abdulkadir NA, et al. Incomplete recovery of erectile function in rat after discontinuation of dual 5-alpha reductase inhibitor therapy. J Sex Med. 2012;9(7):1773–1781. doi:10.1111/j.1743-6109.2012.02759.x | PubMed