Bibliography: Adverse effects of finasteride

This page contains research related to adverse effects of finasteride published since 2000.
See also research by: Symptom | Field of study | Systematic reviews & meta-analyses | Related research
This research briefing summarizes two recent systematic reviews/meta-analyses.

📚 = systematic review / meta-analysis      🧬 = genetics focus      🐀 = animal study

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Birch MR, Dissing S, Skakkebæk NE, Rehfeld A. Finasteride interferes with prostaglandin-induced CatSper-signalling in human sperm. Reproduction. 2021 Mar 1:REP-20-0287.R3. doi:10.1530/REP-20-0287 | PubMed

Burgos-Blasco B, Burgos-Blasco P. Macular Abnormalities Associated With 5α-Reductase Inhibitor. JAMA Ophthalmol. 2021 Feb 1;139(2):251-252. doi: 10.1001/jamaophthalmol.2020.5768 | PubMed

Giatti S, Di Domizio A, Diviccaro S, Falvo E, Caruso D, Contini A, Melcangi RC. Three-Dimensional Proteome-Wide Scale Screening for the 5-Alpha Reductase Inhibitor Finasteride: Identification of a Novel Off-Target. Journal of Medicinal Chemistry. doi:10.1021/acs.jmedchem.0c02039 | PubMed

Kang MJ, Choi JY, Sim WY, Lew BL. 5α-Reductase inhibitors in men aged 50 years or older with androgenetic alopecia: A retrospective study. J Am Acad Dermatol. 2021 Jan;84(1):172-173. doi:10.1016/j.jaad.2020.04.051 | PubMed

Kim JA, Choi D, Choi S, Chang J, Park SM. The Association of 5α-Reductase Inhibitor With Suicidality. Psychosom Med. 2020 Apr;82(3):331-336. doi:10.1097/PSY.0000000000000784 | PubMed

🐀 Kur P, Kolasa-Wołosiuk A, Grabowska M, Kram A, Tarnowski M, Baranowska-Bosiacka I, Rzeszotek S, Piasecka M, Wiszniewska B. The Postnatal Offspring of Finasteride-Treated Male Rats Shows Hyperglycaemia, Elevated Hepatic Glycogen Storage and Altered GLUT2, IR, and AR Expression in the Liver. Int J Mol Sci. 2021 Jan 27;22(3):1242. doi:10.3390/ijms22031242 | PubMed

La Vignera S, Aversa A, Cannarella R, Condorelli RA, Duca Y, Russo GI, Calogero AE. Pharmacological treatment of lower urinary tract symptoms in benign prostatic hyperplasia: consequences on sexual function and possible endocrine effects. Expert Opin Pharmacother. 2021 Feb;22(2):179-189. doi:10.1080/14656566.2020.1817382 | PubMed

Lusty A, Siemens DR, Tohidi M, Whitehead M, Tranmer J, Nickel JC. Cardiac Failure Associated with Medical Therapy of Benign Prostatic Hyperplasia: A Population Based Study. J Urol. 2021 Feb 22:101097JU0000000000001561. doi:10.1097/JU.0000000000001561 | PubMed

Pompili M, Magistri C, Maddalena S, Mellini C, Persechino S, Baldessarini RJ. Risk of Depression Associated With Finasteride Treatment. J Clin Psychopharmacol. 2021 Mar 31. doi:10.1097/JCP.0000000000001379 | PubMed

Shin YK, Kang SW. Macular Abnormalities Associated With 5α-Reductase Inhibitor-Reply. JAMA Ophthalmol. 2021 Feb 1;139(2):252-253. doi:10.1001/jamaophthalmol.2020.5774 | PubMed


🐀 Ahire A, Nair, KP, Shankaranarayana Rao BS, Srikumar BN. The Potential Involvement of Cholinergic System in Finasteride Induced Cognitive Dysfunction. Psychoneuroendocrinology. 2020:105066. In press 18 Nov 2020. doi:10.1016/j.psyneuen.2020.105066 | PubMed

Albasher G, Bin-Jumah M, Alfarraj S, et al. Prolonged use of finasteride-induced gonadal sex steroids alterations, DNA damage and menstrual bleeding in women. Biosci Rep. 2020;40(2):BSR20191434. doi:10.1042/BSR20191434PubMed

Alcántara Montero A, Müller-Arteaga C. 5-alpha reductase inhibitors: New evidences on benefits and harms beyond benign prostatic hyperplasia. Inhibidores de la 5-alfa reductasa: nuevas evidencias sobre los beneficios y los daños más allá de la hiperplasia benigna de próstata. Actas Urol Esp. 2019;43(1):52-53. doi:10.1016/j.acuro.2018.05.003 | PubMed

🐀 Angrimani DSR, Bicudo LC, Llamas Luceño N, et al. Does finasteride treatment for benign prostatic hyperplasia influence sperm DNA integrity in dogs?. Basic Clin Androl. 2020;30:9. doi:10.1186/s12610-020-00108-2 | PubMed

🐀 Angrimani DSR, Brito MM, Rui BR, Nichi M, Vannucchi CI. Reproductive and endocrinological effects of Benign Prostatic Hyperplasia and finasteride therapy in dogs. Sci Rep. 2020;10(1):14834. doi:10.1038/s41598-020-71691-7PubMed

🐀 Angrimani DSR, Francischini MCP, Brito MM, Vannucchi CI. Prostatic hyperplasia: Vascularization, hemodynamic and hormonal analysis of dogs treated with finasteride or orchiectomy. PLoS One. 2020;15(6):e0234714. doi:10.1371/journal.pone.0234714 | PubMed

🐀 Bartolomé I, Llidó A, Darbra S, Pallarès M. Early postnatal neuroactive steroid manipulation differentially affects recognition memory and passive avoidance performance in male rats. Behav Brain Res. 2020;112833. doi:10.1016/j.bbr.2020.112833 | PubMed

Borgo F, Macandog AD, Diviccaro S, Falvo E, Giatti S, Cavaletti G, Melcangi RC. Alterations of gut microbiota composition in post-finasteride patients: a pilot study. J Endocrinol Invest. 2020 Sep 19. doi:10.1007/s40618-020-01424-0 | PubMed

📚 Busetto GM, Del Giudice F, D’Agostino D, et al. Efficacy and safety of Finasteride (5 alpha-reductase inhibitor) monotherapy in patients with benign prostatic hyperplasia: A critical review of the literature. Arch Ital Urol Androl. 2020;91(4):205-210. doi:10.4081/aiua.2019.4.205 | PubMed

📚 Chen L, Zhang J, Wang L, Wang H, Chen B. The Efficacy and Safety of Finasteride Combined with Topical Minoxidil for Androgenetic Alopecia: A Systematic Review and Meta-analysis. Aesthetic Plast Surg. 2020 Jun;44(3):962-970. doi:10.1007/s00266-020-01621-5 | PubMed

🐀 Chen X, Feng H, El-Kott AF, Abd-Ella EM. Origanum vulgare L. leaves extract alleviates testis and sperm damages induced by finasteride: Biochemical, Immunohistological and apoptosis genes based evidences. Andrologia. 2020 Sep 23:e13823. doi:10.1111/and.13823 | PubMed

Deng T, Duan X, He Z, Zhao Z, Zeng G. Association Between 5-Alpha Reductase Inhibitor Use and The Risk of Depression: A Meta-Analysis. Urol J. 2020;10.22037/uj.v16i7.5866. doi:10.22037/uj.v16i7.5866 | PubMed

Dhurat R, Sharma A, Rudnicka L, et al. 5-alpha Reductase Inhibitors in Androgenetic Alopecia: Shifting Paradigms, Current Concepts, Comparative Efficacy and Safety. Dermatol Ther. 2020;10.1111/dth.13379. doi:10.1111/dth.13379PubMed

Dyson TE, Cantrell MA, Lund BC. Lack of Association Between 5α-Reductase Inhibitors and Depression. J Urol. 2020;101097JU0000000000001079. doi:10.1097/JU.0000000000001079 | PubMed

Fang Q, Chen P, Du N, Nandakumar KS. Analysis of Data From Breast Diseases Treated With 5-Alpha Reductase Inhibitors for Benign Prostatic Hyperplasia. Clin Breast Cancer. 2019;19(5):e624-e636. doi:10.1016/j.clbc.2019.04.006 | PubMed

🐀 Gilroy ÈAM, Bartlett AJ, Gillis PL, et al. Toxicity of the pharmaceuticals finasteride and melengestrol acetate to benthic invertebrates. Environ Sci Pollut Res Int. 2020;10.1007/s11356-020-10121-7. doi:10.1007/s11356-020-10121-7 | PubMed

🐀 Golchin-Rad K, Mogheiseh A, Nazifi S, Ahrari Khafi MS, Derakhshandeh N, Abbaszadeh-Hasiri M. Changes in the Serum Prostatic Biomarkers During the Treatment of Benign Prostatic Hyperplasia with a 5alpha-reductase Inhibitor: Finasteride. Top Companion Anim Med. 2020;38:100405. doi:10.1016/j.tcam.2020.100405 | PubMed

🐀 Gul A, Altinay S, Kabasakal L, Yavuz A, Semercioz A, Serefoglu EC. Effect of tadalafil on penile nitric oxide synthase and corporal smooth muscle in rats under dutasteride treatment. Aging Male. 2020 Jun;23(2):161-167. doi:10.1080/13685538.2020.1739019 | PubMed

Gupta MA, Vujcic B, Gupta AK. Finasteride Use Is Associated with Higher Odds of Obstructive Sleep Apnea: Results from the US Food and Drug Administration Adverse Events Reporting System. Skinmed. 2020;18(3):146-150. PubMed

Harrell MB, Ho K, Te AE, Kaplan SA, Chughtai B. An evaluation of the federal adverse events reporting system data on adverse effects of 5-alpha reductase inhibitors. World J Urol. 2020;10.1007/s00345-020-03314-9. doi:10.1007/s00345-020-03314-9 | PubMed

📚 Herz-Ruelas ME, Álvarez-Villalobos NA, Millán-Alanís JM, de León-Gutiérrez H, Ocampo-Garza SS, Gómez-Flores M, Grimalt R. Efficacy of Intralesional and Oral Dutasteride in the Treatment of Androgenetic Alopecia: A Systematic Review. Skin Appendage Disord. 2020 Nov;6(6):338-345. doi:10.1159/000510697 | PubMed

Ho RS. Ongoing Concerns Regarding Finasteride for the Treatment of Male-Pattern Androgenetic Alopecia. JAMA Dermatol. 2020 Nov 11. doi:10.1001/jamadermatol.2020.3384 | PubMed

Iamsumang W, Leerunyakul K, Suchonwanit P. Finasteride and Its Potential for the Treatment of Female Pattern Hair Loss: Evidence to Date. Drug Des Devel Ther. 2020 Mar 2;14:951-959. doi:10.2147/DDDT.S240615 | PubMed

Ihentuge C, Csoka A. Epigenetic Effects of Finasteride on Human Leydig Cells. The FASEB Journal. 2020;34(S1). doi:10.1096/fasebj.2020.34.s1.03823

Irwig MS. Finasteride and Suicide: A Postmarketing Case Series. Dermatology. 2020:1-6. doi:10.1159/000505151 | PubMed

Khera M, Than JK, Anaissie J, et al. Penile vascular abnormalities in young men with persistent side effects after finasteride use for the treatment of androgenic alopecia. Transl Androl Urol. 2020;9(3):1201-1209. doi:10.21037/tau.2020.03.21 | PubMed

Kim JH, Shim SR, Khandwala Y, Del Giudice F, Sorensen S, Chung BI. Risk of Depression after 5 Alpha Reductase Inhibitor Medication: Meta-Analysis. World J Mens Health. 2020 Oct;38(4):535-544. doi:10.5534/wjmh.190046 | PubMed

Kim YJ, Tae BS, Bae JH. Cognitive Function and Urologic Medications for Lower Urinary Tract Symptoms. Int Neurourol J. 2020 Sep;24(3):231-240. doi:10.5213/inj.2040082.041 | PubMed

Kjærulff TM, Ersbøll AK, Pukkala E, et al. Characteristics of finasteride users in comparison with nonusers: A Nordic nationwide study based on individual-level data from Denmark, Finland, and Sweden. Pharmacoepidemiol Drug Saf. 2020;10.1002/pds.4947. doi:10.1002/pds.4947 | PubMed

Kroumpouzos G. Effects of 5-alpha reductase inhibitors on lung function: a reason for discontinuation during COVID-19 pandemic?. Dermatol Ther. 2020;e13535. doi:10.1111/dth.13535 | PubMed

La Vignera S, Aversa A, Cannarella R, et al. Pharmacological treatment of lower urinary tract symptoms in benign prostatic hyperplasia: consequences on sexual function and possible endocrine effects. Expert Opin Pharmacother. 2020;1-11. doi:10.1080/14656566.2020.1817382 | PubMed

Lee YR, Im E, Kim H, et al. Untargeted Metabolomics and Steroid Signatures in Urine of Male Pattern Baldness Patients after Finasteride Treatment for a Year. Metabolites. 2020;10(4):E131. doi:10.3390/metabo10040131 | PubMed

🐀 Maldarine JS, Sanches BDA, Santos VA, Cabral ÁS, Lima MLD, Bedolo CM, Calmon MF, Rahal P, Góes RM, Vilamaior PSL, Taboga SR. Postnatal exposure to finasteride causes different effects on the prostate of male and female gerbils. Cell Biol Int. 2020 Jun;44(6):1341-1352. doi:10.1002/cbin.11328 | PubMed

🐀 Mendell AL, Creighton SD, Wilson HA, Jardine KH, Isaacs L, Winters BD, MacLusky NJ. Inhibition of 5α Reductase Impairs Cognitive Performance, Alters Dendritic Morphology and Increases Tau Phosphorylation in the Hippocampus of Male 3xTg-AD Mice. Neuroscience. 2020 Mar 1;429:185-202. doi:10.1016/j.neuroscience.2020.01.011 | PubMed

🐀 Mohebali S, Hayati Roodbari N, Hajihosseini R, Parivar K. The effects of Finasteride on the expression of Dazl, Tsga10, Sycp3, Prm2 genes during spermatogenesis in testes of NMRI mice. Eur Rev Med Pharmacol Sci. 2020;24(15):8160-8163. doi:10.26355/eurrev_202008_22503 | PubMed

Motofei IG, Rowland DL, Tampa M, et al. Finasteride and androgenic alopecia; from therapeutic options to medical implications. J Dermatolog Treat. 2020;31(4):415-421. doi:10.1080/09546634.2019.1595507 | PubMed

Nguyen DD, Marchese M, Cone EB, Paciotti M, Basaria S, Bhojani N, Trinh QD. Investigation of Suicidality and Psychological Adverse Events in Patients Treated With Finasteride. JAMA Dermatol. 2020 Nov 11;157(1):35–42. doi:10.1001/jamadermatol.2020.3385 | PubMed

🐀 Olayinka ET, Adewole KE. In vivo and in silico evaluation of the ameliorative effect of hesperidin on finasteride-induced testicular oxidative stress in Wistar rats. Toxicol Mech Methods. 2020 Oct 1:1-28. doi:10.1080/15376516.2020.1831123 | PubMed

Othonos N, Marjot T, Woods C, Hazlehurst JM, Nikolaou N, Pofi R, White S, Bonaventura I, Webster C, Duffy J, Cornfield T, Moolla A, Isidori AM, Hodson L, Tomlinson JW. Co-administration of 5α-reductase Inhibitors Worsens the Adverse Metabolic Effects of Prescribed Glucocorticoids. J Clin Endocrinol Metab. 2020 Sep 1;105(9):e3316–28. doi:10.1210/clinem/dgaa408 | PubMed

Pallotti F, Senofonte G, Pelloni M, Cargnelutti F, Carlini T, Radicioni AF, Rossi A, Lenzi A, Paoli D, Lombardo F. Androgenetic alopecia: effects of oral finasteride on hormone profile, reproduction and sexual function. Endocrine. 2020 Feb 12. doi:10.1007/s12020-020-02219-2 | PubMed

Pereira AFJR, Coelho TOA. Post-finasteride syndrome. Anais Brasileiros de Dermatologia. 25 March 2020. doi:10.1016/j.abd.2020.02.001 | PubMed

Rivera Mirabal J, Than J, Annaisie J, Antar A, Song W, Losso B, Pastuszak A, Kohn T, Khera M. 124 The persistent effects of 5α-reductase inhibitors used in the treatment of androgenic alopecia on men’s health. J Sex Med. 2020;17(1):S33–S34. doi:10.1016/j.jsxm.2019.11.070

🐀 Shalaby AM, Alabiad MA, El Shaer DF. Resveratrol Ameliorates the Seminiferous Tubules Damages Induced by Finasteride in Adult Male Rats. Microsc Microanal. 2020 Oct 5:1-11. doi:10.1017/S1431927620024514 | PubMed

Shin YK, Lee GW, Kang SW, Kim SJ, Kim AY. Macular Abnormalities Associated With 5α-Reductase Inhibitor. JAMA Ophthalmol. 2020 Jul 1;138(7):732-739. doi:10.1001/jamaophthalmol.2020.1279 | PubMed

[Letter] Sirufo MM, Ginaldi L, De Martinis M. Bone Health Risks Associated with Finasteride and Dutasteride Long-Term Use. World J Mens Health. 2020 Nov 26. doi:10.5534/wjmh.200138 | PubMed

Suchonwanit P, Iamsumang W, Leerunyakul K. Topical finasteride for the treatment of male androgenetic alopecia and female pattern hair loss: a review of the current literature. J Dermatolog Treat. 2020;1-21. doi:10.1080/09546634.2020.1782324 | PubMed

Traish AM. Health Risks Associated with Long-Term Finasteride and Dutasteride Use: It’s Time to Sound the Alarm. World J Mens Health. 2020;10.5534/wjmh.200012. doi:10.5534/wjmh.200012 | PubMed

Traish AM. Post-finasteride syndrome: a surmountable challenge for clinicians. Fertil Steril. 2020;113(1):21-50. doi:10.1016/j.fertnstert.2019.11.030 | PubMed

Vañó-Galván S, Saceda-Corralo D, Moreno-Arrones OM, Rodrigues-Barata R, Morales C, Gil-Redondo R, Bernárdez-Guerra C, Hermosa-Gelbard Á, Jaén-Olasolo P. Effectiveness and safety of oral dutasteride for male androgenetic alopecia in real clinical practice: A descriptive monocentric study. Dermatol Ther. 2020 Jan;33(1):e13182. doi: 10.1111/dth.13182 | PubMed

Zhou Z, Cui Y, Wu J, Jin H. Efficacy and safety of dutasteride compared with finasteride in treating males with benign prostatic hyperplasia: A meta-analysis of randomized controlled trials. Exp Ther Med. 2020;20(2):1566-1574. doi:10.3892/etm.2020.8851 | PubMed


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🐀 Alkahtane AA, Albasher G, Al-Sultan NK, et al. Long-term treatment with finasteride induces apoptosis and pathological changes in female mice. Hum Exp Toxicol. 2019;38(7):762-774. doi:10.1177/0960327119842195 | PubMed

Andy G, John M, Mirna S, et al. Controversies in the treatment of androgenetic alopecia: The history of finasteride. Dermatol Ther. 2019;32(2):e12647. doi:10.1111/dth.12647 | PubMed

🐀 Baig MS, Kolasa-Wołosiuk A, Pilutin A, et al. Finasteride-Induced Inhibition of 5α-Reductase Type 2 Could Lead to Kidney Damage-Animal, Experimental Study. Int J Environ Res Public Health. 2019;16(10):1726. doi:10.3390/ijerph16101726 | PubMed

🐀 Bartolomé I, Llidó A, Darbra S, Pallarès M. Early postnatal allopregnanolone levels alteration and adult behavioral disruption in rats: Implication for drug abuse. Neurobiol Stress. 2019;12:100208. Published 2019 Dec 27. doi:10.1016/j.ynstr.2019.100208 | PubMed

Catalano A, Martino G, Bellone F, Papalia M, Lasco C, Basile G, Sardella A, Nicocia G, Morabito N, Lasco A. Neuropsychological Assessment in Elderly Men with Benign Prostatic Hyperplasia Treated with Dutasteride. Clin Drug Investig. 2019 Jan;39(1):97-102. Erratum in: Clin Drug Investig. 2018 Nov 26. doi:10.1007/s40261-018-0720-7PubMed

Coskuner ER, Ozkan B, Culha MG. Sexual Problems of Men With Androgenic Alopecia Treated With 5-Alpha Reductase Inhibitors. Sex Med Rev. 2019;7(2):277-282. doi:10.1016/j.sxmr.2018.07.003 | PubMed

🐀 Diviccaro S, Giatti S, Borgo F, et al. Treatment of male rats with finasteride, an inhibitor of 5alpha-reductase enzyme, induces long-lasting effects on depressive-like behavior, hippocampal neurogenesis, neuroinflammation and gut microbiota composition. Psychoneuroendocrinology. 2019;99:206-215. doi:10.1016/j.psyneuen.2018.09.021PubMed

Diviccaro S, Melcangi RC, Giatti S. Post-finasteride syndrome: An emerging clinical problem. Neurobiol Stress. 2019;12:100209. doi:10.1016/j.ynstr.2019.100209 | PubMed

🐀 Fanni S, Scheggi S, Rossi F, et al. 5alpha-reductase inhibitors dampen L-DOPA-induced dyskinesia via normalization of dopamine D1-receptor signaling pathway and D1-D3 receptor interaction. Neurobiol Dis. 2019;121:120–130. doi:10.1016/j.nbd.2018.09.018 | PubMed

🧬 Ghassemi M, Ghaffarpour GH, Ghods S. The effect of GGC and CAG repeat polymorphisms on the androgen receptor gene in response to finasteride therapy in men with androgenetic alopecia. J Res Med Sci. 2019;24:104. doi:10.4103/jrms.JRMS_27_19 | PubMed

🐀 Godar SC, Cadeddu R, Floris G, et al. The Steroidogenesis Inhibitor Finasteride Reduces the Response to Both Stressful and Rewarding Stimuli. Biomolecules. 2019;9(11):749. doi:10.3390/biom9110749 | PubMed

Gray SL, Semla TP. Post-finasteride syndrome. BMJ. 2019;366:l5047. doi:10.1136/bmj.l5047 | PubMed

Haber RS, Gupta AK, Epstein E, Carviel JL, Foley KA. Finasteride for androgenetic alopecia is not associated with sexual dysfunction: a survey-based, single-centre, controlled study. J Eur Acad Dermatol Venereol. 2019;33(7):1393–1397. doi:10.1111/jdv.15548 | PubMed

Kaczmarek IA, Prost ME, Wasyluk J. Clinical risk factors associated with intraoperative floppy iris syndrome: a prospective study. Int Ophthalmol. 2019;39(3):541‐549. doi:10.1007/s10792-018-0840-3 | PubMed

🐀 Kilic S, Kolukcu E, Erdemir F, Benli I, Arici A. The Effects of Oral 5-alpha Reductase Inhibitors on Penile Intracavernosal Pressures and Penile Morphology in Rat Model. Urology J. 2019; 16(2):205–211. doi:10.22037/uj.v0i0.4164 | PubMed

Kjærulff TM, Ersbøll AK, Green A, Emneus M, Brasso K, Iversen P, Pukkala E, Bolin K, Thygesen LC. Finasteride Use and Risk of Male Breast Cancer: A Case-Control Study Using Individual-Level Registry Data from Denmark, Finland, and Sweden. Cancer Epidemiol Biomarkers Prev. 2019 May;28(5):980-986. doi:10.1158/1055-9965.EPI-18-0904 | PubMed

📚 Lee S, Lee YB, Choe SJ, Lee WS. Adverse Sexual Effects of Treatment with Finasteride or Dutasteride for Male Androgenetic Alopecia: A Systematic Review and Meta-analysis. Acta Derm Venereol. 2019;99(1):12–17. doi:10.2340/00015555-3035 | PubMed

Lee SG, Park PJ, Lee SR, Koo BH, Byun GY, Kim MJ, Kang HJ, Kim S, Oh BS, Lee YH. Influence of Postoperative Finasteride Therapy on Recurrence of Gynecomastia After Mastectomy in Men Taking Finasteride for Alopecia. Am J Mens Health. 2019 Sep-Oct;13(5):1557988319871423. doi:10.1177/1557988319871423 | PubMed

Maksym RB, Kajdy A, Rabijewski M. Post-finasteride syndrome – does it really exist? Aging Male. 2019;22(4):250–259. doi:10.1080/13685538.2018.1548589 | PubMed

🐀 Maldarine JS, Sanches BDA, Cabral ÁS, et al. Prenatal exposure to finasteride promotes sex-specific changes in gerbil prostate development. Reprod Fertil Dev. 2019;31(11):1719-1729. doi:10.1071/RD19106 | PubMed

Marks DH, Prasad S, De Souza B, Burns LJ, Senna MM. Topical Antiandrogen Therapies for Androgenetic Alopecia and Acne Vulgaris. Am J Clin Dermatol. 2019 Dec 12. doi:10.1007/s40257-019-00493-z | PubMed

🧬 Melcangi RC, Casarini L, Marino M, et al. Altered methylation pattern of the SRD5A2 gene in the cerebrospinal fluid of post-finasteride patients: a pilot study. Endocr Connect. 2019;8(8):1118-1125. doi:10.1530/EC-19-0199 | PubMed

🐀 Sasibhushana RB, Shankaranarayana Rao BS, Srikumar BN. Repeated finasteride administration induces depression-like behavior in adult male rats. Behav Brain Res. 2019;365:185–189. doi:10.1016/j.bbr.2019.03.006 | PubMed

Shin YS, Karna KK, Choi BR, Park JK. Finasteride and Erectile Dysfunction in Patients with Benign Prostatic Hyperplasia or Male Androgenetic Alopecia. World J Mens Health. 2019;37(2):157–165. doi:10.5534/wjmh.180029 | PubMed

🐀 Sung HH, Yu J, Kang SJ, et al. Persistent Erectile Dysfunction after Discontinuation of 5-Alpha Reductase Inhibitor Therapy in Rats Depending on the Duration of Treatment. World J Mens Health. 2019;37(2):240–248. doi:10.5534/wjmh.180082 | PubMed

📚 Traish AM, Krakowsky Y, Doros G, Morgentaler A. Do 5α-Reductase Inhibitors Raise Circulating Serum Testosterone Levels? A Comprehensive Review and Meta-Analysis to Explaining Paradoxical Results. Sex Med Rev. 2019;7(1):95-114. doi:10.1016/j.sxmr.2018.06.002 | PubMed

Trüeb RM, Régnier A, Dutra Rezende H, Gavazzoni Dias MFR. Post-Finasteride Syndrome: An Induced Delusional Disorder with the Potential of a Mass Psychogenic Illness? Skin Appendage Disord. 2019;5(5):320-326. doi:10.1159/000497362 | PubMed

Wei L, Lai EC, Kao-Yang YH, Walker BR, MacDonald TM, Andrew R. Incidence of type 2 diabetes mellitus in men receiving steroid 5α-reductase inhibitors: population based cohort study. BMJ. 2019;365:l1204. doi:10.1136/bmj.l1204 | PubMed

📚 Zakhem GA, Goldberg JE, Motosko CC, Cohen BE, Ho RS. Sexual dysfunction in men taking systemic dermatologic medication: A systematic review. J Am Acad Dermatol. 2019;81(1):163-172. doi:10.1016/j.jaad.2019.03.043 | PubMed

📚 Zhou Z, Song S, Gao Z, Wu J, Ma J, Cui Y. The efficacy and safety of dutasteride compared with finasteride in treating men with androgenetic alopecia: a systematic review and meta-analysis. Clin Interv Aging. 2019;14:399-406. doi:10.2147/CIA.S192435 | PubMed


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AlSaad D, Lee BH, Al-Obaidly S. Finasteride use during pregnancy and early neonatal outcome: a case report. Int J Clin Pharm. 2018;40(4):803-805. doi:10.1007/s11096-018-0661-5 | PubMed

Antoniou T, Macdonald EM, Yao Z, et al. A population-based study of the risk of osteoporosis and fracture with dutasteride and finasteride. BMC Musculoskelet Disord. 2018;19(1):160. Published 2018 May 22. doi:10.1186/s12891-018-2076-9 | PubMed

Andrade C. Why Odds Ratios Can Be Tricky Statistics: The Case of Finasteride, Dutasteride, and Sexual Dysfunction. J Clin Psychiatry. 2018;79(6). doi:10.4088/JCP.18f12641

Baas WR, Butcher MJ, Lwin A, et al. A Review of the FAERS Data on 5-Alpha Reductase Inhibitors: Implications for Postfinasteride Syndrome. Urology. 2018;120:143-149. doi:10.1016/j.urology.2018.06.022 | PubMed

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McVary KT, Rogers T, Mahon J, Gupta NK. Is Sexual Function Better Preserved After Water Vapor Thermal Therapy or Medical Therapy for Lower Urinary Tract Symptoms due to Benign Prostatic Hyperplasia?. J Sex Med. 2018;15(12):1728–1738. doi:10.1016/j.jsxm.2018.10.006 | PubMed

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Arif T, Dorjay K, Adil M, Sami M. Dutasteride in Androgenetic Alopecia: An Update. Curr Clin Pharmacol. 2017;12(1):31–35. doi:10.2174/1574884712666170310111125 | PubMed

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Narasimhalu CR. Randomized Questionnaire Based Case-Control Research Study on Evaluation of Sexual Function in Indian Patients Taking Oral Finasteride for Androgenetic Alopecia. Dermatol Ther (Heidelb). 2015;5(4):231-234. doi:10.1007/s13555-015-0084-3 | PubMed

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Perez-Mora N, Velasco C, Bermüdez F. Oral Finasteride Presents With Sexual-Unrelated Withdrawal in Long-Term Treated Androgenic Alopecia in Men. Skinmed. 2015;13(3):179-183. PubMed

Stojanović N, Ignjatović I, Djenić N, Bogdanović D. Adverse Effects of Pharmacological Therapy of Benign Prostatic Hyperplasia on Sexual Function in Men. Srp Arh Celok Lek. 2015;143(5-6):284–289. doi:10.2298/sarh1506284s | PubMed

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Traish AM, Haider KS, Doros G, Haider A. Finasteride, not tamsulosin, increases severity of erectile dysfunction and decreases testosterone levels in men with benign prostatic hyperplasia. Horm Mol Biol Clin Investig. 2015;23(3):85-96. doi:10.1515/hmbci-2015-0015 | PubMed

Traish AM, Melcangi RC, Bortolato M, Garcia-Segura LM, Zitzmann M. Adverse effects of 5α-reductase inhibitors: What do we know, don’t know, and need to know? Rev Endocr Metab Disord. 2015;16(3):177-198. doi:10.1007/s11154-015-9319-y | PubMed


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Ryu HJ, Kwon DY. Reversible myopathy and ophthalmoparesis after low-dose finasteride administration for androgenic alopecia. Dermatol Surg. 2014;40(5):595-597. doi:10.1111/dsu.12458 | PubMed

Singh MK, Avram M. Persistent sexual dysfunction and depression in finasteride users for male pattern hair loss: a serious concern or red herring? J Clin Aesthet Dermatol. 2014;7(12):51-55. PubMed

🐀 Singh S, Moksha L, Sharma N, Titiyal JS, Biswas NR, Velpandian T. Development and evaluation of animal models for sex steroid deficient dry eye. J Pharmacol Toxicol Methods. 2014;70(1):29–34. doi:10.1016/j.vascn.2014.03.004 | PubMed

Traish AM, Guay AT, Zitzmann M. 5α-Reductase inhibitors alter steroid metabolism and may contribute to insulin resistance, diabetes, metabolic syndrome and vascular disease: a medical hypothesis. Horm Mol Biol Clin Investig. 2014;20(3):73-80. doi:10.1515/hmbci-2014-0025 | PubMed

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Stanczyk FZ, Azen CG, Pike MC. Effect of finasteride on serum levels of androstenedione, testosterone and their 5α-reduced metabolites in men at risk for prostate cancer. J Steroid Biochem Mol Biol. 2013;138:10–16. doi:10.1016/j.jsbmb.2013.02.015 | PubMed

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Tu HY, Zini A. Finasteride-induced secondary infertility associated with sperm DNA damage. Fertil Steril. 2011;95(6):2125.e13–2125.e14. doi:10.1016/j.fertnstert.2010.12.061 | PubMed


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Darbra S, Pallarès M. Alterations in neonatal neurosteroids affect exploration during adolescence and prepulse inhibition in adulthood. Psychoneuroendocrinology. 2010;35(4):525-535. doi:10.1016/j.psyneuen.2009.08.020 | PubMed

Lynn R, Krunic A. Therapeutic hotline. Treatment of androgenic alopecia with finasteride may result in a high grade prostate cancer in patients: fact or fiction?. Dermatol Ther. 2010;23(5):544-546. doi:10.1111/j.1529-8019.2010.01358.x | PubMed

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Wong AC, Mak ST. Finasteride-associated cataract and intraoperative floppy-iris syndrome. J Cataract Refract Surg. 2011;37(7):1351‐1354. doi:10.1016/j.jcrs.2011.04.013 | PubMed


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Anitha B, Inamadar AC, Ragunatha S. Finasteride-its impact on sexual function and prostate cancer. J Cutan Aesthet Surg. 2009;2(1):12-16. doi:10.4103/0974-2077.53093

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Amory JK, Anawalt BD, Matsumoto AM, et al. The effect of 5alpha-reductase inhibition with dutasteride and finasteride on bone mineral density, serum lipoproteins, hemoglobin, prostate specific antigen and sexual function in healthy young men. J Urol. 2008;179(6):2333-2338. doi:10.1016/j.juro.2008.01.145 | PubMed

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Al Hammadi A, Asai Y, Patt ML, Sasseville D. Erythema annulare centrifugum secondary to treatment with finasteride. J Drugs Dermatol. 2007;6(4):460-463. PubMed

Amory JK, Wang C, Swerdloff RS, et al. The effect of 5alpha-reductase inhibition with dutasteride and finasteride on semen parameters and serum hormones in healthy men [published correction appears in J Clin Endocrinol Metab. 2007 Nov;92(11):4379]. J Clin Endocrinol Metab. 2007;92(5):1659–1665. doi:10.1210/jc.2006-2203 | PubMed

Bortolato M, Muroni A, Marrosu F. Treatment of Tourette’s syndrome with finasterideAm J Psychiatry. 2007 Dec;164(12):1914-5. doi:10.1176/appi.ajp.2007.07060978 | PubMed

Finasteride: new indication. Benign prostatic hypertrophy: sexual disorders. Prescrire Int. 2007;16(90):147. Journal site

Moinpour CM, Darke AK, Donaldson GW, et al. Longitudinal analysis of sexual function reported by men in the Prostate Cancer Prevention Trial. J Natl Cancer Inst. 2007;99(13):1025-1035. doi:10.1093/jnci/djm023 | PubMed

Mondaini N, Gontero P, Giubilei G, et al. Finasteride 5 mg and sexual side effects: how many of these are related to a nocebo phenomenon? J Sex Med. 2007;4(6):1708-1712. doi:10.1111/j.1743-6109.2007.00563.x | PubMed

Naslund MJ, Miner M. A review of the clinical efficacy and safety of 5alpha-reductase inhibitors for the enlarged prostate. Clin Ther. 2007;29(1):17-25. doi:10.1016/j.clinthera.2007.01.018 | PubMed


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🐀 de Brito Faturi C, Teixeira-Silva F, Leite JR. The anxiolytic effect of pregnancy in rats is reversed by finasteride. Pharmacol Biochem Behav. 2006;85(3):569-574. doi:10.1016/j.pbb.2006.10.011 | PubMed

Carson CC. Combination of phosphodiesterase-5 inhibitors and alpha-blockers in patients with benign prostatic hyperplasia: treatments of lower urinary tract symptoms, erectile dysfunction, or both? BJU Int. 2006;97 Suppl 2:39-43; discussion 44-5. doi:10.1111/j.1464-410X.2006.06105.x

Finn DA, Beadles-Bohling AS, Beckley EH, et al. A new look at the 5alpha-reductase inhibitor finasteride. CNS Drug Rev. 2006;12(1):53-76. doi:10.1111/j.1527-3458.2006.00053.x

Giuliano F. Impact of medical treatments for benign prostatic hyperplasia on sexual function. BJU Int. 2006;97 Suppl 2:34-38; discussion 44-5. doi:10.1111/j.1464-410X.2006.06104.x

🐀 Mann PE. Finasteride delays the onset of maternal behavior in primigravid rats. Physiol Behav. 2006;88(4-5):333-338. doi:10.1016/j.physbeh.2006.04.008 | PubMed

Miner M, Rosenberg MT, Perelman MA. Treatment of lower urinary tract symptoms in benign prostatic hyperplasia and its impact on sexual function. Clin Ther. 2006;28(1):13-25. doi:10.1016/j.clinthera.2006.01.004

Rahimi-Ardabili B, Pourandarjani R, Habibollahi P, Mualeki A. Finasteride induced depression: a prospective study. BMC Clin Pharmacol. 2006;6:7. doi:10.1186/1472-6904-6-7 | PubMed

🐀 Robaire B, Henderson NA. Actions of 5alpha-reductase inhibitors on the epididymis. Mol Cell Endocrinol. 2006;250(1-2):190–195. doi:10.1016/j.mce.2005.12.044 | PubMed

Ryu HK, Kim KM, Yoo EA, Sim WY, Chung BC. Evaluation of androgens in the scalp hair and plasma of patients with male-pattern baldness before and after finasteride administration. Br J Dermatol. 2006;154(4):730‐734. doi:10.1111/j.1365-2133.2005.07072.x | PubMed


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Djavan B, Milani S, Fong YK. Dutasteride: a novel dual inhibitor of 5alpha-reductase for benign prostatic hyperplasia. Expert Opin Pharmacother. 2005;6(2):311-317. doi:10.1517/14656566.6.2.311

Kuritzky L. Noninvasive management of lower urinary tract symptoms and sexual dysfunction associated with benign prostatic hyperplasia in the primary care setting. Compr Ther. 2005;31(3):194-208. doi:10.1385/comp:31:3:194

Marihart S, Harik M, Djavan B. Dutasteride: a review of current data on a novel dual inhibitor of 5alpha reductase. Rev Urol. 2005;7(4):203-210. PubMed

McVary KT. Sexual Function and α-Blockers. Rev Urol. 2005;7(Suppl 8):S3-S11. PubMed

Paick SH, Meehan A, Lee M, Penson DF, Wessells H. The relationship among lower urinary tract symptoms, prostate specific antigen and erectile dysfunction in men with benign prostatic hyperplasia: results from the proscar long-term efficacy and safety study. J Urol. 2005;173(3):903-907. doi:10.1097/01.ju.0000152088.00361.a7

🐀 Ribeiro CM, Pereira OC. 5alpha-reductase 2 inhibition impairs brain defeminization of male rats: reproductive aspects. Pharmacol Biochem Behav. 2005;82(1):228-235. doi:10.1016/j.pbb.2005.08.015

Rosen RC, Giuliano F, Carson CC. Sexual dysfunction and lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). Eur Urol. 2005;47(6):824–837. doi:10.1016/j.eururo.2004.12.013 | PubMed

📚 Thomson A. Dutasteride: an evidence-based review of its clinical impact in the treatment of benign prostatic hyperplasia. Core Evid. 2005;1(2):143-156. PubMed

🧬 Wakisaka N, Taira Y, Ishikawa M, et al. Effectiveness of finasteride on patients with male pattern baldness who have different androgen receptor gene polymorphism. J Investig Dermatol Symp Proc. 2005;10(3):293-294. doi:10.1111/j.0022-202X.2005.10123.x | PubMed


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Glina S, Neves PA, Saade R, Netto NR Jr, Soares JB, Galuppo AG. Finasteride-associated male infertility. Rev Hosp Clin Fac Med Sao Paulo. 2004 Aug;59(4):203-5. doi:10.1590/s0041-87812004000400009 | PubMed

Klein EA, Thompson IM. Update on chemoprevention of prostate cancer. Curr Opin Urol. 2004;14(3):143-149. doi:10.1097/00042307-200405000-00002 | PubMed

Pitts WR Jr. Finasteride (Propecia) and the promotion of high-grade prostate cancer. Arch Dermatol. 2004;140(7):885‐886. doi:10.1001/archderm.140.7.885-b | PubMed

Tosti A, Pazzaglia M, Soli M, et al. Evaluation of sexual function with an international index of erectile function in subjects taking finasteride for androgenetic alopecia. Arch Dermatol. 2004;140(7):857-858. doi:10.1001/archderm.140.7.857 | PubMed


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Altomare G, Capella GL. Depression circumstantially related to the administration of finasteride for androgenetic alopecia. J Dermatol. 2002;29(10):665–669. doi:10.1111/j.1346-8138.2002.tb00200.x | PubMed

[Comment] Pope JE, Makela EH. Response to article “Depression circumstantially related to the administration of finasteride for androgenetic alopecia” (J Dermatol, 29, 665-669, 2002). J Dermatol. 2003;30(11):837–844. doi:10.1111/j.1346-8138.2003.tb00488.x | PubMed

🐀 Bowman CJ, Barlow NJ, Turner KJ, Wallace DG, Foster PM. Effects of in utero exposure to finasteride on androgen-dependent reproductive development in the male rat. Toxicol Sci. 2003;74(2):393-406. doi:10.1093/toxsci/kfg128

Carbone DJ, Hodges S. Medical therapy for benign prostatic hyperplasia: sexual dysfunction and impact on quality of life. Int J Impot Res. 2003;15(4):299-306. doi:10.1038/sj.ijir.3901017

Kassabian VS. Sexual function in patients treated for benign prostatic hyperplasia. Lancet. 2003;361(9351):60-62. doi:10.1016/S0140-6736(03)12164-2 | PubMed

Larson TR. Current treatment options for benign prostatic hyperplasia and their impact on sexual function. Urology. 2003;61(4):692-698. doi:10.1016/s0090-4295(02)02552-9

Lowe FC, McConnell JD, Hudson PB, et al. Long-term 6-year experience with finasteride in patients with benign prostatic hyperplasia. Urology. 2003;61(4):791-796. doi:10.1016/s0090-4295(02)02548-7

McConnell JD, Roehrborn CG, Bautista OM, et al. The long-term effect of doxazosin, finasteride, and combination therapy on the clinical progression of benign prostatic hyperplasia. N Engl J Med. 2003;349(25):2387–2398. doi:10.1056/NEJMoa030656 | PubMed

Roehrborn CG, Lee M, Meehan A, Waldstreicher J, Group PS. Effects of finasteride on serum testosterone and body mass index in men with benign prostatic hyperplasia. Urology. 2003;62(5):894-899. doi:10.1016/s0090-4295(03)00661-7

Sadeghi-Nejad H, Sherman N, Lue J. Comparison of finasteride and alpha-blockers as independent risk factors for erectile dysfunction. Int J Clin Pract. 2003;57(6):484-487. PubMed

Thompson IM, Goodman PJ, Tangen CM, et al. The influence of finasteride on the development of prostate cancer. N Engl J Med. 2003;349(3):215-224. doi:10.1056/NEJMoa030660 | PubMed

Thompson IM, Klein EA, Lippman SM, Coltman CA, Djavan B. Prevention of prostate cancer with finasteride: US/European perspective. Eur Urol. 2003;44(6):650-655. doi:10.1016/j.eururo.2003.11.001

Wessells H, Roy J, Bannow J, et al. Incidence and severity of sexual adverse experiences in finasteride and placebo-treated men with benign prostatic hyperplasia. Urology. 2003;61(3):579-584. doi:10.1016/s0090-4295(02)02401-9

Whiting DA, Olsen EA, Savin R, et al. Efficacy and tolerability of finasteride 1 mg in men aged 41 to 60 years with male pattern hair loss. Eur J Dermatol. 2003;13(2):150-160. PubMed


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📚 Edwards JE, Moore RA. Finasteride in the treatment of clinical benign prostatic hyperplasia: a systematic review of randomised trials. BMC Urol. 2002;2:14. doi:10.1186/1471-2490-2-14

Ferrando J, Grimalt R, Alsina M, Bulla F, Manasievska E. Unilateral gynecomastia induced by treatment with 1 mg of oral finasteride. Arch Dermatol. 2002;138(4):543‐544. doi:10.1001/archderm.138.4.543 | PubMed

🐀 Huynh H. Induction of apoptosis in rat ventral prostate by finasteride is associated with alteration in MAP kinase pathways and Bcl-2 related family of proteins. Int J Oncol. 2002;20(6):1297-1303. PubMed

Leliefeld HH, Stoevelaar HJ, McDonnell J. Sexual function before and after various treatments for symptomatic benign prostatic hyperplasia. BJU Int. 2002;89(3):208-213. doi:10.1046/j.1464-4096.2001.01817.x

Price VH, Menefee E, Sanchez M, Ruane P, Kaufman KD. Changes in hair weight and hair count in men with androgenetic alopecia after treatment with finasteride, 1 mg, daily. J Am Acad Dermatol. 2002;46(4):517–523. doi:10.1067/mjd.2002.120537 | PubMed

🐀 Rhoden EL, Gobbi D, Menti E, Rhoden C, Telöken C. Effects of the chronic use of finasteride on testicular weight and spermatogenesis in Wistar rats. BJU Int. 2002 Jun;89(9):961-3. doi:10.1046/j.1464-410x.2002.02785.x | PubMed


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🐀 Dadras SS, Cai X, Abasolo I, Wang Z. Inhibition of 5alpha-reductase in rat prostate reveals differential regulation of androgen-response gene expression by testosterone and dihydrotestosterone. Gene Expr. 2001;9(4-5):183–194. doi:10.3727/000000001783992551 | PubMed

Kaplan SA. 5alpha-reductase inhibitors: what role should they play?. Urology. 2001;58(6 Suppl 1):65–70. doi:10.1016/s0090-4295(01)01347-4 | PubMed

Kaplan SA, Holtgrewe HL, Bruskewitz R, et al. Comparison of the efficacy and safety of finasteride in older versus younger men with benign prostatic hyperplasia. Urology. 2001;57(6):1073–1077. doi:10.1016/s0090-4295(01)00985-2 | PubMed

O’Leary MP. Quality of life and sexuality: methodological aspects. Eur Urol. 2001;40 Suppl 3:13-18. doi:10.1159/000049886

Pole M, Koren G. Finasteride. Does it affect spermatogenesis and pregnancy?. Can Fam Physician. 2001;47:2469–2470. PMC full text | PubMed

Schulman C. Impact of treatment of BPH on sexuality. Prostate Cancer Prostatic Dis. 2001;4(S1):S12-S16. doi:10.1038/sj.pcan.4500541

Stoevelaar HJ, McDonnell J. Changing therapeutic regimens in benign prostatic hyperplasia. Clinical and economic considerations. Pharmacoeconomics. 2001;19(2):131-153. doi:10.2165/00019053-200119020-00003 | PubMed

Tosti A, Piraccini BM, Soli M. Evaluation of sexual function in subjects taking finasteride for the treatment of androgenetic alopecia. J Eur Acad Dermatol Venereol. 2001;15(5):418-421. doi:10.1046/j.1468-3083.2001.00315.x | PubMed

Wise GJ, Md EO. Hormonal treatment of patients with benign prostatic hyperplasia: pros and cons. Curr Urol Rep. 2001;2(4):285-291. doi:10.1007/s11934-001-0065-1


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Clifford GM, Farmer RD. Medical therapy for benign prostatic hyperplasia: a review of the literature. Eur Urol. 2000;38(1):2-19. doi:10.1159/000020246

Van Neste D, Fuh V, Sanchez-Pedreno P, et al. Finasteride increases anagen hair in men with androgenetic alopecia. Br J Dermatol. 2000;143(4):804-810. doi:10.1046/j.1365-2133.2000.03780.x | PubMed

For older papers see Early research (1974–1999)