Research: 2020–present
See also: History of research • On-ramp for researchers • Special topics
🐀 = animal study 🧬 = genetics focus 📚 = systematic review / meta-analysis
All periods: 2020–present | 2015–2019 | 2010–2014 | 2000–2009 | 1942–1999
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2023
Cancer
Dekalo S, McArthur E, Campbell J, Ordon M, Power N, Welk B. 5α-reductase inhibitors and the risk of bladder cancer in a large, population-based cohort. Urol Oncol. 2023. doi:10.1016/j.urolonc.2022.09.004 • PubMed
Doherty N, Cardwell CR, Murchie P, Hill C, Azoulay L, Hicks B. 5-alpha reductase inhibitors and risk of kidney and bladder cancers in men with benign prostatic hyperplasia: a population-based cohort study. Cancer Epidemiol Biomarkers Prev. 2023 Jan 12. doi:10.1158/1055-9965.EPI-22-1109 • PubMed
Dermatology
Nobari NN, Roohaninasab M, Sadeghzadeh-Bazargan A, et al. A systematic review of clinical trials using single or combination therapy of oral or topical finasteride for women in reproductive age and postmenopausal women with hormonal and nonhormonal androgenetic alopecia. Adv Clin Exp Med. 2023. doi:10.17219/acem/157990 • PubMed
Pharmacovigilance & drug safety
Nguyen DD, Herzog P, Cone EB, et al. Disproportional signal of sexual dysfunction reports associated with finasteride use in young men with androgenetic alopecia: a pharmacovigilance analysis of VigiBase. J Am Acad Dermatol. 2023. doi:10.1016/j.jaad.2022.03.037 • PubMed
2022
Cancer
Björnebo L, Nordström T, Discacciati A, et al. Association of 5α-reductase inhibitors with prostate cancer mortality. JAMA Oncol. 2022 Jul 1. doi:10.1001/jamaoncol.2022.1501. Erratum in: JAMA Oncol. 2022 Jun 16. PubMed
Garg H, Wheeler KM, Dursun F, et al. Impact of finasteride on survival in bladder cancer: a retrospective multi-institutional database analysis. Clin Genitourin Cancer. 2022 Oct. doi:10.1016/j.clgc.2022.10.014 • PubMed
Rabbani S, Santoni G, Lagergren J, Xie SH. Use of anti-androgenic 5α-reductase inhibitors and risk of oesophageal and gastric cancer by histological type and anatomical sub-site. Br J Cancer. 2022 Jun 17. doi:10.1038/s41416-022-01872-w • PubMed
Dermatology
[⚠️ Funded by GSK] Choi GS, Sim WY, Kang H, et al. Long-term effectiveness and safety of dutasteride versus finasteride in patients with male androgenic alopecia in South Korea: a multicentre chart review study. Ann Dermatol. 2022 Oct. doi:10.5021/ad.22.027 • PubMed
🐀 da Cruz GK, Martins MIM, Antunes FTT, et al. Evaluation of the efficacy and toxicity of oral and topical pumpkin oil on the hair growth of mice. Acta Histochem. 2022 Apr 18. doi:10.1016/j.acthis.2022.151894 • PubMed [Includes finasteride treatment group]
Gupta AK, Talukder M. Topical finasteride for male and female pattern hair loss: Is it a safe and effective alternative? J Cosmet Dermatol. 2022 May. doi:10.1111/jocd.14895 • PubMed
Gupta AK, Talukder M, Williams G. Comparison of oral minoxidil, finasteride, and dutasteride for treating androgenetic alopecia. J Dermatolog Treat. 2022 Aug 3. doi:10.1080/09546634.2022.2109567 • PubMed
Huang KP, Senna MM. Hair are the rankings—5-α reductase inhibitors and minoxidil in male androgenetic alopecia. JAMA Dermatol. 2022 Feb 2. doi:10.1001/jamadermatol.2021.5625 • PubMed
Hui EX, Huang X, Oon HH. Review of dermatologic medications and impact on male fertility, sexual dysfunction and teratogenicity. Andrology. 2022 Oct. doi:10.1111/andr.13236 • PubMed
Melo DF, Saceda-Corralo D, Tosti A. Frontal edema due to mesotherapy for androgenetic alopecia: a case series. Dermatol Ther. 2022 Feb. doi:10.1111/dth.15247 • PubMed
[⚠️ Funded by Polichem & Almirall] Piraccini BM, Blume-Peytavi U, Scarci F, et al. Efficacy and safety of topical finasteride spray solution for male androgenetic alopecia: a phase III, randomized, controlled clinical trial. J Eur Acad Dermatol Venereol. 2022. doi:10.1111/jdv.17738. Erratum in: J Eur Acad Dermatol Venereol. 2023. PubMed • PMC full text
Reguero Del Cura L, De Quintana Sancho A, Rubio Lombraña M, López Sundh AE, González López MA. Two cases of paradoxical nonscarring alopecia after mesotherapy with dutasteride. Skin Appendage Disord. 2022 Jan. doi:10.1159/000518043 • PubMed
Sand J, Walen S. Noninvasive hair rejuvenation. Facial Plast Surg Clin North Am. 2022 Aug. doi:10.1016/j.fsc.2022.03.015 • PubMed
Trüeb RM, Luu NC, Gavazzoni Dias MFR, Dutra Rezende H. How to deal with the issues of fertility, malignancies, and the postfinasteride syndrome while prescribing finasteride for male pattern hair loss. Skin Appendage Disord. 2022 May. doi:10.1159/000520493 • PubMed
Yanagisawa M, Sato A. Long-term (over 10 years) evaluation of efficacy and safety of finasteride in Japanese men with androgenetic alopecia: summary of three investigations. Hair Transplant Forum International. 2022 Jul;32(4):130-132. doi:10.33589/32.4.130.
Hepatology
Rzeszotek S, Kolasa A, Pilutin A, Misiakiewicz-Has K, Sielatycka K, Wiszniewska B. The interplay between finasteride-induced androgen imbalance, endoplasmic reticulum stress, oxidative stress, and liver disorders in paternal and filial generation. Biomedicines. 2022. doi:10.3390/biomedicines10112725
Metabolomics & genomics
🧬 Surendran P, Stewart ID, Au Yeung VPW, et al. Rare and common genetic determinants of metabolic individuality and their effects on human health. Nat Med. 2022. doi:10.1038/s41591-022-02046-0 • PubMed • PMC full text
Neuroendocrinology & neuropharmacology
🐀 Dhillon HK, Singh T, Goel RK. Ferulic acid inhibits catamenial epilepsy through modulation of female hormones. Metab Brain Dis. 2022 Aug 6. doi:10.1007/s11011-022-01054-w • PubMed [Finasteride increased seizure susceptibility and depression-like characteristics]
🐀 Diviccaro S, Giatti S, Cioffi L, et al. Gut inflammation induced by finasteride withdrawal: therapeutic effect of allopregnanolone in adult male rats. Biomolecules. 2022. doi:10.3390/biom12111567 • Link via journal
Ocular effects
Calvao J, Feijão J, Soares RO. Finasteride and floppy iris syndrome: What role can the dermatologist play? [Letter]. Int J Trichology. 2022 May-Jun. doi:10.4103/ijt.ijt_118_20 • PubMed • PMC full text
📚 Christou CD, Esagian SM, Ziakas N, Prousali E, Tzamalis A. Factors predisposing to intraoperative floppy iris syndrome (IFIS): an updated systematic review and meta-analysis. J Cataract Refract Surg. 2022 Jul 20. doi:10.1097/j.jcrs.0000000000001017 • PubMed
Pharmacovigilance & drug safety
Asanad K, Sholklapper T, Samplaski MK, Cacciamani GE. Global online interest in finasteride sexual side effects. Int J Impot Res. 2022. doi:10.1038/s41443-022-00612-1 • PubMed
Garcia-Argibay M, Hiyoshi A, Fall K, Montgomery S. Association of 5α-reductase inhibitors with dementia, depression, and suicide. JAMA Netw Open. 2022. doi:10.1001/jamanetworkopen.2022.48135 • PubMed
Gordijn R, Wessels W, Kriek E, et al. Patient reporting of sexual adverse events on an online platform for medication experiences. Br J Clin Pharmacol. 2022 Jul 2. doi:10.1111/bcp.15454 • PubMed
Hui EX, Huang X, Oon HH. Review of dermatologic medications and impact on male fertility, sexual dysfunction and teratogenicity. Andrology. 2022 Oct. doi:10.1111/andr.13236 • PubMed
Kaplan-Marans E, Sandozi A, Martinez M, Lee J, Schulman A, Khurgin J. Medications most commonly associated with erectile dysfunction: evaluation of the Food and Drug Administration national pharmacovigilance database. Sex Med. 2022. doi:10.1016/j.esxm.2022.100543 (full text available) • PubMed
Schifano N, Capogrosso P, Boeri L, et al. Are finasteride-related penile curvature/Peyronie’s disease adverse event reports worthy of further clinical investigation? Disproportionality analysis based on both the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) pharmacovigilance databases. Int J Impot Res. 2022 May 5. doi:10.1038/s41443-022-00568-2 • PubMed
Valeiro C, Matos C, Scholl J, van Hunsel F. Drug-induced sexual dysfunction: an analysis of reports to a national pharmacovigilance database. Drug Saf. 2022 Apr 7. doi:10.1007/s40264-022-01174-3 • PubMed
Yeon B, Suh AY, Choi E, et al. Depression risk associated with the use of 5α-reductase inhibitors versus α-blockers: a retrospective cohort study in South Korea. PLoS One. 2022 Mar 16. doi:10.1371/journal.pone.0265169 • PubMed • PMC full text
📚 Zhang JJ, Shi X, Wu T, et al. Sexual, physical, and overall adverse effects in patients treated with 5α-reductase inhibitors: a systematic review and meta-analysis. Asian J Androl. 2022 Jul-Aug. doi:10.4103/aja202171 • PubMed
See also: In Dermatology: Hui et al., 2022. In Post-finasteride syndrome: Irwig, 2022.
Post-finasteride syndrome
Alhetheli GI, Alrashidi FH, Alhammad SH. Post-finasteride syndrome: current views and where do we stand?. Ann Med Health Sci Res. 2022 Jan 24. doi:10.54608/annalsmedical.2022.23 • via Internet Archive
Irwig MS. How routine pharmacovigilance failed to identify finasteride’s persistent sexual side effects. Andrology. 2022. doi:10.1111/andr.13122 • PubMed
🧬 Li X, Guo Y, Lu Y, et al. Case report: a study of the clinical characteristics and genetic variants of post-finasteride syndrome patients. Transl Androl Urol. 2022 Oct. doi:10.21037/tau-22-92 • PubMed • PMC full text
Romero Pérez P. Post-finasteride syndrome. Literature review. Arch Esp Urol. 2022 Jun. doi:10.56434/j.arch.esp.urol.20227505.56 • PubMed
See also: In Dermatology: Trüeb et al., 2022. In Pharmacovigilance & drug safety: Schifano et al., 2022; and Zhang et al., 2022.
Urology & sexual medicine
🐀 Flores RB, Angrimani DSR, Brito MM, et al. Frozen-thawed sperm analysis of benign prostatic hyperplasia dogs treated with finasteride. Front Vet Sci. 2022 Jun 30. doi:10.3389/fvets.2022.901943 • PubMed • PMC full text
📚 Li Y, Ma J, Qin XH, Hu CY. The efficacy and safety of dutasteride and finasteride in patients with benign prostatic hyperplasia: a systematic review and meta-analysis. Transl Androl Urol. 2022 Mar. doi:10.21037/tau-22-58 • PubMed • PMC full text
[⚠️ Funded by NeoTract/Teleflex, seller of UroLift System] Roehrborn CG, Rukstalis DB. Prostatic urethral lift versus medical therapy: examining the impact on sexual function in men with benign prostatic hyperplasia. Eur Urol Focus. 2022 Jan. doi:10.1016/j.euf.2020.12.013 • PubMed
🐀 Yilmaz-Oral D, Onder A, Kaya-Sezginer E, Oztekin CV, Zor M, Gur S. Restorative effects of red onion (Allium cepa L.) juice on erectile function after-treatment with 5α-reductase inhibitor in rats. Int J Impot Res. 2022 Apr. doi:10.1038/s41443-021-00421-y • PubMed
See also: In Dermatology: Hui et al., 2022.
2022 abstracts & preprints
Brezis M. Neuropsychiatric reactions to finasteride: nocebo or true effect? Authorea. 2022 Aug 10. doi:10.22541/au.166012115.57216742/v1
Campbell K, Velazquez O, Sullivan J, Lipshultz L. Finasteride-associated suicide and depression in men treated for hypogonadism and impotence. J Sex Med. 2022;19(4):S4-S5. doi:10.1016/j.jsxm.2022.01.019 • Abstract with chart (PDF) • 2021 poster • See also video interview in Grey literature: Presentations & webinars
Carlisle M, Uloko M, Yee A, Goldstein S, Goldstein I. Vascular, neurologic and hormonal abnormalities in men with persistent sexual dysfunction after discontinuation of finasteride. J Urol. 2022 May 1;207(5S):e620–621. doi:10.1097/JU.0000000000002592.07 • Poster (PDF)
Fusaroli M, Simonsen A, Borrie SA, et al. Identifying medications underlying communication atypicalities in psychotic and affective disorders: a pharmacovigilance study within the FDA Adverse Event Reporting System. medRxiv. Published online 2022. doi:10.1101/2022.09.05.22279609
🐀 Giatti S, Diviccaro S, Di Domizio A, et al. Finasteride inhibits epinephrine synthesis in humans: implication for sexual dysfunction. Endocrine Abstracts. 2022 May;81:P448. doi:10.1530/endoabs.81.P448
🧬 Ihentuge C, Csoka A. Finasteride induces epigenetic modulation of LSP1: a gene implicated in neutrophil actin dysfunction disease. FASEB J. 2022 May;36 Suppl 1. doi:10.1096/fasebj.2022.36.S1.R4708
Kaplan-Marans E, Martinez M, Sandozi A, Lee J, Khurgin J, Schulman A. PD49-02 Medications most commonly associated with erectile dysfunction: evaluation of the Food and Drug Administration national pharmacovigilance database. J Urol. 2022 May;207 Suppl 5:e830. doi:10.1097/JU.0000000000002620.02 [See paper in Sex Med above]
Nguyen BJ, Meer E, Gupta AS, et al. The effect of finasteride on dry eye disease. Paper presented at: ARVO 2022: Annual Meeting of the Association for Research in Vision and Ophthalmology; May 1, 2022; Denver, CO. Abstract (PDF)
Nguyen D, Herzog P, Cone EB, et al. Pharmacovigilance analysis of reports of sexual dysfunction associated with finasteride use: implications for the post-finasteride syndrome. J Sex Med. 2022;19(5, Supplement 2):S130-S131. doi:10.1016/j.jsxm.2022.03.553 • Direct link on journal website
Nguyen DD, Herzog P, Cone EB, et al. Pharmacovigilance analysis of reports of sexual dysfunction associated with finasteride use: implications for the post-finasteride syndrome (342494). Poster presented at: 41st Congress of the Société Internationale d’Urologie / SIU Academy; November 12, 2021; Dubai, United Arab Emirates. Poster
2021
Dermatology
Gupta AK, Venkataraman M, Talukder M, Bamimore MA. Finasteride for hair loss: a review. J Dermatolog Treat. 2021 Jul 22. doi:10.1080/09546634.2021.1959506 • PubMed
Kang MJ, Choi JY, Sim WY, Lew BL. 5α-reductase inhibitors in men aged 50 years or older with androgenetic alopecia: a retrospective study. J Am Acad Dermatol. 2021 Jan. doi:10.1016/j.jaad.2020.04.051 • PubMed
Nestor MS, Ablon G, Gade A, Han H, Fischer DL. Treatment options for androgenetic alopecia: efficacy, side effects, compliance, financial considerations, and ethics. J Cosmet Dermatol. 2021 Nov 6. doi:10.1111/jocd.14537 • PubMed
Rokni GR, Mohammadnezhad F, Saeedi M, et al. Efficacy, tolerability, and safety of montelukast versus finasteride for the treatment of moderate acne in women: A prospective, randomized, single-blinded, active-controlled trial. J Cosmet Dermatol. 2021 Oct 14. doi:10.1111/jocd.14462 • PubMed
Sattur SS, Sattur IS. Pharmacological management of pattern hair loss. Indian J Plast Surg. 2021 Dec. doi:10.1055/s-0041-1739254 • PubMed • PMC full text
Trüeb RM. Understanding pattern hair loss—hair biology impacted by genes, androgens, prostaglandins and epigenetic factors. Indian J Plast Surg. 2021 Dec. doi:10.1055/s-0041-1739252 • PubMed • PMC full text
Yamada T. Photosensitivity reaction induced by finasteride. J Gen Fam Med. 2021 Nov 5. doi:10.1002/jgf2.510 • PubMed • PMC full text
Legal matters
Low P, Li KD, Hakam N, et al. 5-alpha reductase inhibitor related litigation: a legal database review. Andrology. 2021 Dec 21. doi:10.1111/andr.13145 • PubMed
Microbiome
Borgo F, Macandog AD, Diviccaro S, et al. Alterations of gut microbiota composition in post-finasteride patients: a pilot study. J Endocrinol Invest. 2021 Jun. doi:10.1007/s40618-020-01424-0. PubMed • PMC full text
Nephrology
🐀 Da Silva MHA, Estrada JHD, Gregório BM, et al. Does treatment with dutasteride or finasteride has [sic] impact on renal morphology? Experimental study. Acta Cir Bras. 2021 Sep 15. doi:10.1590/ACB360703 • PubMed • PMC full text
Pharmacology & neuroendocrinology
🐀 Ahire A, Nair, KP, Shankaranarayana Rao BS, Srikumar BN. The potential involvement of cholinergic system in finasteride induced cognitive dysfunction. Psychoneuroendocrinology. 2021 Feb. doi:10.1016/j.psyneuen.2020.105066 • PubMed
Favilla V, Cannarella R, Trovato F, et al. Effects of dutasteride on sex hormones and cerebrospinal steroids in patients treated for benign prostatic hyperplasia. Endocrine. 2021 Sep. doi:10.1007/s12020-021-02675-4 • PubMed
Giatti S, Di Domizio A, Diviccaro S, et al. Three-dimensional proteome-wide scale screening for the 5-alpha reductase inhibitor finasteride: identification of a novel off-target. J Med Chem. 2021 Apr 22. doi:10.1021/acs.jmedchem.0c02039 • PubMed • PMC full text
Saengmearnuparp T, Lojanapiwat B, Chattipakorn N, Chattipakorn S. The connection of 5-alpha reductase inhibitors to the development of depression. Biomed Pharmacother. 2021 Aug 31. doi:10.1016/j.biopha.2021.112100 • PubMed • Full text via ScienceDirect
🧬 Villapalos-García G, Zubiaur P, et al. Effects of cytochrome P450 and transporter polymorphisms on the bioavailability and safety of dutasteride and tamsulosin. Front Pharmacol. 2021 Oct 7. doi:10.3389/fphar.2021.718281 • PubMed • PMC full text
Pharmacovigilance & drug safety
Ayodele O, Cabral HJ, McManus D, Jick S. The risk of venous thromboembolism (VTE) in men with benign prostatic hyperplasia treated with 5-alpha reductase inhibitors (5ARIs). Clin Epidemiol. 2021 Aug 3. doi:10.2147/CLEP.S317019 • PubMed • PMC full text
Bearelly P, Avellino GJ. The role of benign prostatic hyperplasia treatments in ejaculatory dysfunction. Fertil Steril. 2021 Sep. doi:10.1016/j.fertnstert.2021.07.1199 • PubMed
Gallo E, Maggini V, Lombardi N, et al. Serenoa repens induced erectile dysfunction: underdiagnosis and phytovigilance. Br J Clin Pharmacol. 2021 Nov 7. doi:10.1111/bcp.15129 • PubMed
Johnstone J, Lusty A, Tohidi M, et al. The association of new-onset diabetes mellitus and medical therapy for benign prostatic hyperplasia: a population-based study. Can Urol Assoc J. 2021 Aug. doi:10.5489/cuaj.7489 • PubMed • PMC full text
La Torre A, Palleria C, Tamanini I, et al. Sexual dysfunctions related to drugs used in the management of lower urinary tract symptoms due to benign prostatic hyperplasia: a narrative review on α-blockers and 5-alpha reductase inhibitors. Uro. 2021. doi:10.3390/uro1030012
La Vignera S, Aversa A, Cannarella R, et al. Pharmacological treatment of lower urinary tract symptoms in benign prostatic hyperplasia: consequences on sexual function and possible endocrine effects. Expert Opin Pharmacother. 2021 Feb. doi:10.1080/14656566.2020.1817382 • PubMed
Lulic Z, Son H, Yoo SB, et al. Free combination of dutasteride plus tamsulosin for the treatment of benign prostatic hyperplasia in South Korea: analysis of drug utilization and adverse events using the National Health Insurance Review and Assessment Service database. BMC Urol. 2021 Dec 21. doi:10.1186/s12894-021-00941-1 • PubMed • PMC full text
Lusty A, Siemens DR, Tohidi M, Whitehead M, Tranmer J, Nickel JC. Cardiac failure associated with medical therapy of benign prostatic hyperplasia: a population based study. J Urol. 2021 Feb 22. doi:10.1097/JU.0000000000001561 • PubMed
📚 Pompili M, Magistri C, Maddalena S, Mellini C, Persechino S, Baldessarini RJ. Risk of depression associated with finasteride treatment. J Clin Psychopharmacol. 2021 May-Jun. doi:10.1097/JCP.0000000000001379 • PubMed
[Follow-up research letter] Baldessarini RJ, Pompili M. Further studies of effects of finasteride on mood and suicidal risk. J Clin Psychopharmacol. 2021 Nov-Dec 01. doi:10.1097/JCP.0000000000001485 • PubMed
Velez D, Ohlander S. Medical therapies causing iatrogenic male infertility. Fertil Steril. 2021 Sep. doi:10.1016/j.fertnstert.2021.07.1202 • PubMed
Post-finasteride syndrome
Healy D, Bahrick A, Bak M, et al. Diagnostic criteria for enduring sexual dysfunction after treatment with antidepressants, finasteride and isotretinoin. Int J Risk Saf Med. 2021 Oct 26. doi:10.3233/JRS-210023 • PubMed • PMC full text
🧬 Howell S, Song W, Pastuszak A, Khera M. Differential gene expression in post-finasteride syndrome patients. J Sex Med. 2021 Sep. doi:10.1016/j.jsxm.2021.05.009 • PubMed
Oztekin CV, Yilmaz-Oral D, Kaya-Sezginer E, et al. Beneficial effects of human umbilical cord blood mononuclear cells on persistent erectile dysfunction after treatment of 5-alpha reductase inhibitor in rats. J Sex Med. 2021 May. doi:10.1016/j.jsxm.2021.02.005 • PubMed
Reproductive toxicology
Birch MR, Dissing S, Skakkebæk NE, Rehfeld A. Finasteride interferes with prostaglandin-induced CatSper-signalling in human sperm. Reproduction. 2021 Mar 1. doi:10.1530/REP-20-0287 • PubMed
🐀 🧬 Kolasa A, Rogińska D, Rzeszotek S, Machaliński B, Wiszniewska B. Paternal finasteride treatment can influence the testicular transcriptome profile of male offspring—preliminary study. Curr Issues Mol Biol. 2021 Jul 31. doi:10.3390/cimb43020062 • PubMed
🐀 🧬 Kur P, Kolasa-Wołosiuk A, Grabowska M, et al. The postnatal offspring of finasteride-treated male rats shows hyperglycaemia, elevated hepatic glycogen storage and altered GLUT2, IR, and AR expression in the liver. Int J Mol Sci. 2021 Jan 27. doi:10.3390/ijms22031242 • PubMed • PMC full text
Transgender medicine
Gao JL, Streed CG Jr, Thompson J, Dommasch ED, Peebles JK. Androgenetic alopecia in transgender and gender diverse populations: a review of therapeutics. J Am Acad Dermatol. 2021 Oct. doi:10.1016/j.jaad.2021.08.067 • PubMed
Urology & andrology
🐀 Lima CB, Angrimani DSR, Flores RB, Vannucchi CI. Endocrine, prostatic vascular, and proapoptotic changes in dogs with benign prostatic hyperplasia treated medically or surgically. Domest Anim Endocrinol. 2021 Apr. doi:10.1016/j.domaniend.2020.106601 • PubMed
Loughlin KR. The clinical applications of five-alpha reductase inhibitors. Can J Urol. 2021 Apr. PubMed • Full text at journal site
2021 abstracts
Asanad K, Cacciamani GE, Samplaski MK. Consulting “Dr. Google” for finasteride sexual side effects: a contemporary worldwide trends analysis. Fertil Steril. 2021 Sep 1;Suppl 3. doi:10.1016/j.fertnstert.2021.07.912
De Nunzio C, Nacchia A, Lombardo R, et al. Sexual adverse events-related to dutasteride and finasteride: Analysis of real-life data from EudraVigilance database. Presented at 36th Annual EAU Congress (virtual). European Urology. 2021 Jun 1;Suppl 1. doi:10.1016/S0302-2838(21)00427-9
Nguyen DD, Herzog P, Cone EB, et al. Disproportional signal of sexual dysfunction reports associated with finasteride use in young men with androgenetic alopecia: pharmacovigilance analysis of VigiBase. Poster presented at: 22nd Annual Fall Meeting of SMSNA; October 21–24, 2021; Scottsdale, AZ. Poster
Schifano N, Capogrosso P, Boeri L, et al. SC36 – Is finasteride intake associated with penile curvature/Peyronie’s Disease? Assessment of both the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) pharmacovigilance databases. European Urology Open Science. 2021 Oct;32(Suppl 1);S18. doi:10.1016/S2666-1683(21)00727-8 • PDF at ScienceDirect. [See also Schifano et al, 2022 above]
2020
COVID-19
Kroumpouzos G. Effects of 5-alpha reductase inhibitors on lung function: a reason for discontinuation during COVID-19 pandemic?. Dermatol Ther. 2020. doi:10.1111/dth.13535 • PubMed
Dermatology
📚 Chen L, Zhang J, Wang L, Wang H, Chen B. The efficacy and safety of finasteride combined with topical minoxidil for androgenetic alopecia: a systematic review and meta-analysis. Aesthetic Plast Surg. 2020 Jun. doi:10.1007/s00266-020-01621-5 • PubMed
Dhurat R, Sharma A, Rudnicka L, et al. 5-alpha reductase inhibitors in androgenetic alopecia: shifting paradigms, current concepts, comparative efficacy, and safety. Dermatol Ther. 2020 May. doi:10.1111/dth.13379 • PubMed
Espasandín-Arias M, García-Rodiño S, Suárez-Peñaranda JM, Rodríguez-Granados MT. Photosensitivity associated with dutasteride therapy. J Dtsch Dermatol Ges. 2020 Apr. doi:10.1111/ddg.14062 • PubMed
📚 Herz-Ruelas ME, Álvarez-Villalobos NA, Millán-Alanís JM, et al. Efficacy of intralesional and oral dutasteride in the treatment of androgenetic alopecia: a systematic review. Skin Appendage Disord. 2020 Nov. doi:10.1159/000510697 • PubMed
Iamsumang W, Leerunyakul K, Suchonwanit P. Finasteride and its potential for the treatment of female pattern hair loss: evidence to date. Drug Des Devel Ther. 2020 Mar 2. doi:10.2147/DDDT.S240615 • PubMed
Motofei IG, Rowland DL, Tampa M, et al. Finasteride and androgenic alopecia; from therapeutic options to medical implications. J Dermatolog Treat. 2020. doi:10.1080/09546634.2019.1595507 • PubMed
Magdaleno-Tapial J, Valenzuela-Oñate C, García-Legaz-Martínez M, et al. Angioedema-like contact dermatitis caused by mesotherapy with dutasteride. Contact Dermatitis. 2020 Sep. doi:10.1111/cod.13585 • PubMed
Ruiz-Villaverde R, Ayen-Rodriguez A, Llamas-Molina JM. Quiz your knowledge: polycyclic annular plaques on the trunk following dutasteride treatment. Eur J Dermatol. 2020 Aug 1. doi:10.1684/ejd.2020.3823 • PubMed
Suchonwanit P, Iamsumang W, Leerunyakul K. Topical finasteride for the treatment of male androgenetic alopecia and female pattern hair loss: a review of the current literature. J Dermatolog Treat. 2020. doi:10.1080/09546634.2020.1782324 • PubMed
Vañó-Galván S, Saceda-Corralo D, Moreno-Arrones OM, et al. Effectiveness and safety of oral dutasteride for male androgenetic alopecia in real clinical practice: a descriptive monocentric study. Dermatol Ther. 2020 Jan. doi:10.1111/dth.13182 • PubMed
See also: Lehmann, 2020 in Legal matters.
Endocrinology
Lee YR, Im E, Kim H, et al. Untargeted metabolomics and steroid signatures in urine of male pattern baldness patients after finasteride treatment for a year. Metabolites. 2020. doi:10.3390/metabo10040131 • PubMed
Othonos N, Marjot T, Woods C, et al. Co-administration of 5α-reductase inhibitors worsens the adverse metabolic effects of prescribed glucocorticoids. J Clin Endocrinol Metab. 2020 Sep 1. doi:10.1210/clinem/dgaa408 • PubMed
Traish AM. Health risks associated with long-term finasteride and dutasteride use: It’s time to sound the alarm. World J Mens Health. 2020 Jul. doi:10.5534/wjmh.200012 • PubMed • PMC full text
[Letter] Sirufo MM, Ginaldi L, De Martinis M. Bone health risks associated with finasteride and dutasteride long-term use. World J Mens Health. 2020 Nov 26. 10.5534/wjmh.200138 • PubMed
Xu W, Schiffer L, Qadir MMF, et al. Intracrine testosterone activation in human pancreatic β-cells stimulates insulin secretion. Diabetes. 2020 Nov. doi:10.2337/db20-0228 • PubMed • PMC full text
Environmental toxicology
🐀 Gilroy ÈAM, Bartlett AJ, Gillis PL, et al. Toxicity of the pharmaceuticals finasteride and melengestrol acetate to benthic invertebrates. Environ Sci Pollut Res Int. 2020. doi:10.1007/s11356-020-10121-7 • PubMed
Legal matters
Lehmann P. [Post-finasteride-syndrome after prescription of 1 mg finasteride-tablet as a treatment for androgenetic hair loss]. Akt Dermatol. 2020. German; abstract in English. doi:10.1055/a-1023-3102
Neurology (case report)
Choi BK, Cheon K, Cho BH, Jung JW, Lee KY. Cerebral venous sinus thrombosis associated with dutasteride use. Yonsei Med J. 2020 Jun. doi:10.3349/ymj.2020.61.6.553 • PubMed • PMC full text
Neuropharmacology & neuroendocrinology
🐀 Bartolomé I, Llidó A, Darbra S, Pallarès M. Early postnatal neuroactive steroid manipulation differentially affects recognition memory and passive avoidance performance in male rats. Behav Brain Res. 2020. doi:10.1016/j.bbr.2020.112833 • PubMed
🐀 Mendell AL, Creighton SD, Wilson HA, et al. Inhibition of 5α reductase impairs cognitive performance, alters dendritic morphology and increases tau phosphorylation in the hippocampus of male 3xTg-AD mice. Neuroscience. 2020 Mar 1. doi:10.1016/j.neuroscience.2020.01.011 • PubMed
Ophthalmology
Fraunfelder, F. Chapter 7: Hormones and drugs affecting hormonal mechanisms. Drug-Induced Ocular Side Effects. 8th Edition. Elsevier; 2020.
Shin YK, Lee GW, Kang SW, Kim SJ, Kim AY. Macular abnormalities associated with 5α-reductase inhibitor. JAMA Ophthalmol. 2020 Jul 1. doi:10.1001/jamaophthalmol.2020.1279 • PubMed
[Letter] Burgos-Blasco B, Burgos-Blasco P. Macular abnormalities associated with 5α-reductase inhibitor. JAMA Ophthalmol. 2021 Feb 1. 10.1001/jamaophthalmol.2020.5768 • PubMed
[Reply] Shin YK, Kang SW. Macular abnormalities associated with 5α-reductase inhibitor-Reply. JAMA Ophthalmol. 2021 Feb 1. 10.1001/jamaophthalmol.2020.5774 • PubMed
Pharmacovigilance & drug safety
Bonde Miranda T, Garmo H, Stattin P, Robinson D. 5α-reductase inhibitors and risk of prostate cancer death. J Urol. 2020 Oct. doi:10.1097/JU.0000000000001038 • PubMed
📚 Deng T, Duan X, He Z, Zhao Z, Zeng G. Association between 5-alpha reductase inhibitor use and the risk of depression: a meta-analysis. Urol J. 2020 Aug 23. doi:10.22037/uj.v16i7.5866 • PubMed
Dyson TE, Cantrell MA, Lund BC. Lack of association between 5α-reductase inhibitors and depression. J Urol. 2020. doi:10.1097/JU.0000000000001079 • PubMed
Fang Q, Chen P, Du N, Nandakumar KS. Analysis of data from breast diseases treated with 5-alpha reductase inhibitors for benign prostatic hyperplasia. Clin Breast Cancer. 2019. doi:10.1016/j.clbc.2019.04.006 • PubMed
Gupta MA, Vujcic B, Gupta AK. Finasteride use is associated with higher odds of obstructive sleep apnea: results from the US Food and Drug Administration Adverse Events Reporting System. Skinmed. 2020. PubMed
Harrell MB, Ho K, Te AE, Kaplan SA, Chughtai B. An evaluation of the federal adverse events reporting system data on adverse effects of 5-alpha reductase inhibitors. World J Urol. 2020. doi:10.1007/s00345-020-03314-9 • PubMed
Ho RS. Ongoing concerns regarding finasteride for the treatment of male-pattern androgenetic alopecia. JAMA Dermatol. 2020 Nov 11. doi:10.1001/jamadermatol.2020.3384 • PubMed
Irwig MS. Finasteride and suicide: a postmarketing case series. Dermatology. 2020. doi:10.1159/000505151 • PubMed
Kim JA, Choi D, Choi S, Chang J, Park SM. The association of 5α-reductase inhibitor with suicidality. Psychosom Med. 2020 Apr. doi:10.1097/PSY.0000000000000784 • PubMed
📚 Kim JH, Shim SR, Khandwala Y, Del Giudice F, Sorensen S, Chung BI. Risk of depression after 5 alpha reductase inhibitor medication: meta-analysis. World J Mens Health. 2020 Oct. doi:10.5534/wjmh.190046 • PubMed
Kim YJ, Tae BS, Bae JH. Cognitive function and urologic medications for lower urinary tract symptoms. Int Neurourol J. 2020 Sep. doi:10.5213/inj.2040082.041 • PubMed
Kjærulff TM, Ersbøll AK, Pukkala E, et al. Characteristics of finasteride users in comparison with nonusers: A Nordic nationwide study based on individual-level data from Denmark, Finland, and Sweden. Pharmacoepidemiol Drug Saf. 2020. doi:10.1002/pds.4947 • PubMed
Nguyen DD, Marchese M, Cone EB, et al. Investigation of suicidality and psychological adverse events in patients treated with finasteride. JAMA Dermatol. 2020 Nov 11. doi:10.1001/jamadermatol.2020.3385 • PubMed
[Comment] Choi JW, Huh CH, Choi GS. Association of hair loss with suicidality and psychological adverse events vs finasteride use. JAMA Dermatol. 2021 Jun 1. doi:10.1001/jamadermatol.2021.1001 • PubMed
[Reply] Nguyen DD, Cone EB, Trinh QD. Association of hair loss with suicidality and psychological adverse events vs finasteride use-Reply. JAMA Dermatol. 2021 Jun 1. doi:10.1001/jamadermatol.2021.0377 • PubMed
📚 Wang L, Lei Y, Gao Y, Cui D, Tang Q, Li R, Wang D, Chen Y, Zhang B, Wang H. Association of finasteride with prostate cancer: a systematic review and meta-analysis. Medicine (Baltimore). 2020 Apr. doi:10.1097/MD.0000000000019486 • PubMed • PMC full text
See also: Post-finasteride syndrome
Post-finasteride syndrome
Frye CA, DaCosta D, Lembo VF, Walf AA. Advances in knowledge of androgens: how intentional and accidental neurosteroid changes inform us of their action and role.Curr Sex Health Rep. 2020;12:209–220. doi:10.1007/s11930-020-00276-2
Galushkin AA, Likhikh DG, Kogan MI. [Post-finasteride syndrome: our current knowledge]. Vestnik Urologii. 2020;8(2):50-54. Russian. doi:10.21886/2308-6424-2020-8-2-50-54 • Translation (PDF)
Kaur KK, Allahbadia G, Singh M. Post-finasteride syndrome – When will we get the courage to fight the dictating pharma industry – despite awareness of “sexual, neurological and metabolic side effects in young men for over a decade.” Arch Urol. 2020. doi:10.22259/2638-5228.0301003
Khera M, Than JK, Anaissie J, et al. Penile vascular abnormalities in young men with persistent side effects after finasteride use for the treatment of androgenic alopecia. Transl Androl Urol. 2020. doi:10.21037/tau.2020.03.21 • PubMed • PMC full text
Moghalu O, Hotaling J, Pastuszak A. Psychiatric comorbidities and sexual health. Curr Sex Health Rep. 2020. doi:10.1007/s11930-020-00264-6
Pereira AFJR, Coelho TOA. Post-finasteride syndrome. Anais Brasileiros de Dermatologia. 2020 Mar 25. doi:10.1016/j.abd.2020.02.001 • PubMed
Traish AM. Post-finasteride syndrome: a surmountable challenge for clinicians. Fertil Steril. 2020. doi:10.1016/j.fertnstert.2019.11.030 • PubMed
See also: Lehmann, 2020 in Legal matters.
Reproductive medicine
🧬 Albasher G, Bin-Jumah M, Alfarraj S, et al. Prolonged use of finasteride-induced gonadal sex steroids alterations, DNA damage and menstrual bleeding in women. Biosci Rep. 2020. doi:10.1042/BSR20191434 • PubMed
See also: Urology & andrology
Urology & andrology
🐀 Angrimani DSR, Bicudo LC, Llamas Luceño N, et al. Does finasteride treatment for benign prostatic hyperplasia influence sperm DNA integrity in dogs?. Basic Clin Androl. 2020. doi:10.1186/s12610-020-00108-2 • PubMed
🐀 Angrimani DSR, Brito MM, Rui BR, Nichi M, Vannucchi CI. Reproductive and endocrinological effects of benign prostatic hyperplasia and finasteride therapy in dogs. Sci Rep. 2020. doi:10.1038/s41598-020-71691-7 • PubMed
🐀 Angrimani DSR, Francischini MCP, Brito MM, Vannucchi CI. Prostatic hyperplasia: vascularization, hemodynamic and hormonal analysis of dogs treated with finasteride or orchiectomy. PLoS One. 2020. doi:10.1371/journal.pone.0234714 • PubMed
📚 Busetto GM, Del Giudice F, D’Agostino D, et al. Efficacy and safety of finasteride (5 alpha-reductase inhibitor) monotherapy in patients with benign prostatic hyperplasia: a critical review of the literature. Arch Ital Urol Androl. 2020. doi:10.4081/aiua.2019.4.205 • PubMed
🐀 Chen X, Feng H, El-Kott AF, Abd-Ella EM. Origanum vulgare L. leaves extract alleviates testis and sperm damages induced by finasteride: biochemical, immunohistological and apoptosis genes based evidences [sic]. Andrologia. 2020 Dec. doi:10.1111/and.13823 • PubMed
🐀 Da Silva MHA, Medeiros JL Jr, Costa WS, Sampaio FJB, De Souza DB. Effects of the dutasteride and sildenafil association in the penis of a benign prostatic hyperplasia animal model. Aging Male. 2020 Dec. doi:10.1080/13685538.2019.1653839 • PubMed • Journal full text
🐀 Golchin-Rad K, Mogheiseh A, Nazifi S, Ahrari Khafi MS, Derakhshandeh N, Abbaszadeh-Hasiri M. Changes in the serum prostatic biomarkers during the treatment of benign prostatic hyperplasia with a 5alpha-reductase inhibitor: finasteride. Top Companion Anim Med. 2020. doi:10.1016/j.tcam.2020.100405 • PubMed
🐀 Gul A, Altinay S, Kabasakal L, Yavuz A, Semercioz A, Serefoglu EC. Effect of tadalafil on penile nitric oxide synthase and corporal smooth muscle in rats under dutasteride treatment. Aging Male. 2020 Jun. doi:10.1080/13685538.2020.1739019 • PubMed
Kuno T, Uchida Y, Usami T, et al. A young male of [sic] hemorrhagic cerebral infarction associated with finasteride and minoxidil. Nosotchu. 2020;42(4):244-247. Japanese. doi:10.3995/jstroke.10722 • ResearchGate • Automated translation to English (unofficial)
La Vignera S, Aversa A, Cannarella R, et al. Pharmacological treatment of lower urinary tract symptoms in benign prostatic hyperplasia: consequences on sexual function and possible endocrine effects. Expert Opin Pharmacother. 2020. doi:10.1080/14656566.2020.1817382 • PubMed
🐀 Maldarine JS, Sanches BDA, Santos VA, et al. Postnatal exposure to finasteride causes different effects on the prostate of male and female gerbils. Cell Biol Int. 2020 Jun. doi:10.1002/cbin.11328 • PubMed
🐀 Mohebali S, Hayati Roodbari N, Hajihosseini R, Parivar K. The effects of finasteride on the expression of DAZL, TSGA10, SCYP3, PRM2 genes during spermatogenesis in testes of NMRI mice. Eur Rev Med Pharmacol Sci. 2020. doi:10.26355/eurrev_202008_22503 • PubMed
🐀 Olayinka ET, Adewole KE. In vivo and in silico evaluation of the ameliorative effect of hesperidin on finasteride-induced testicular oxidative stress in Wistar rats. Toxicol Mech Methods. 2020 Oct 1. doi:10.1080/15376516.2020.1831123 • PubMed
Pallotti F, Senofonte G, Pelloni M, et al. Androgenetic alopecia: effects of oral finasteride on hormone profile, reproduction and sexual function. Endocrine. 2020 Feb 12. doi:10.1007/s12020-020-02219-2 • PubMed
🐀 Shalaby AM, Alabiad MA, El Shaer DF. Resveratrol ameliorates the seminiferous tubules damages induced by finasteride in adult male rats. Microsc Microanal. 2020 Oct 5. doi:10.1017/S1431927620024514 • PubMed
📚 Zhou Z, Cui Y, Wu J, Jin H. Efficacy and safety of dutasteride compared with finasteride in treating males with benign prostatic hyperplasia: a meta-analysis of randomized controlled trials. Exp Ther Med. 2020. doi:10.3892/etm.2020.8851 • PubMed
2020 abstracts
🧬 Ihentuge C, Csoka A. Epigenetic effects of finasteride on human Leydig cells. The FASEB Journal. Supplement: Experimental Biology 2020 Meeting Abstracts. 2020;S1. doi:10.1096/fasebj.2020.34.s1.03823
Rivera Mirabal J, Than J, Annaisie J, et al. 124 The persistent effects of 5α-reductase inhibitors used in the treatment of androgenic alopecia on men’s health. J Sex Med. 2020;Suppl. doi:10.1016/j.jsxm.2019.11.070
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