Simple summary: Numerous studies have shown that treatment with finasteride and dutasteride can change the size, tissue composition and function of the prostate and penis. In the prostate, treatment with finasteride or dutasteride is linked to: reduced size and weight; tissue atrophy; fewer blood microvessels; and decreases in substances involved in erectile function and maintenance … Read more
Summary This post documents adverse events (AEs) of finasteride affecting male reproductive anatomy and sexual function in men age 18–40, which were reported to US FDA and downloaded from the Federal Adverse Event Reporting System Public Dashboard. The data range is January 1, 2000 to December 31, 2020. This shows AEs assigned to categories which … Read more
This post covers researchers who have published at least three papers on adverse effects of finasteride and 5-alpha reductase inhibitors when taken as a treatment for hair loss, typically by younger men. Collectively, this group has published more than 60 papers on this topic. Keep in mind these caveats: This list does not represent all … Read more
By arrangement with the publisher, full text of the following paper is available: Howell S, Song W, Pastuszak A, Khera M. Differential Gene Expression in Post-Finasteride Syndrome Patients. J Sex Med. 2021;18(9):1479–1490. doi:10.1016/j.jsxm.2021.05.009. PMID: 34247957. Abstract Background An organic etiology underpinning post-finasteride syndrome, a constellation of persistent sexual, neuropsychiatric, and somatic symptoms reported by men … Read more
Even 30 days after stopping paroxetine, the treatment group had significant differences in neuroactive steroids and associated enzymes, in brain areas which help govern emotion, behavior and sexuality.
Summary The Sexual Medicine Society of North America hosted a webinar including a talk about sexual dysfunction induced by finasteride and SSRIs. A study by Baylor researchers finding altered gene expression in post-finasteride patients was published in the Journal of Sexual Medicine. The FDA added a new adverse event to the Propecia label: Hematospermia. The … Read more
Summary It cannot simultaneously be true that finasteride is considered “safe” as a treatment for male pattern hair loss and that the drug causes severe and permanent sexual dysfunction in some men. Since 2011, dozens of papers have investigated its adverse effects, with some concluding that finasteride is safe for treating hair loss despite complaints … Read more
In the last three years, over 100 papers have been published related to adverse effects of finasteride. It can be hard to keep up with this volume of research output. This post offers highlights of two systematic reviews/meta-analyses. These types of papers select and aggregate findings across studies done in the past. Elevated risk of … Read more