A rebuttal to yet another analysis of finasteride adverse events: Nguyen et al, 2022

This post responds to a recent research letter, Nguyen et al, 2022, published in the Journal of the American Academy of Dermatology. Originally posted on Twitter, the thread is reproduced below. Bolding has been added for easier scanning. See also: a critique of three previous papers with similar designs, findings and conclusions. Twitter thread Nguyen … Read more

Tapped by Merck for litigation defense, a clinician-researcher sowed doubts about finasteride harms

A 2018 article disclosed that Dr. Kevin McVary had been retained as an expert for Merck’s defense in litigation regarding persistent adverse effects (AEs) of finasteride.1 Dr. McVary has also been relatively active as a contributor of three conference abstracts, an original article, an expert review, a quote in a media story and a symposium presentation … Read more

Responding to a literature of doubt: limitations of three studies of adverse events of finasteride and dutasteride

A fourth study has been published in the ‘literature of doubt’. Read the rebuttal Three studies analyzing adverse event (AE) data related to finasteride and dutasteride were published from 2018–2020 (the “AE papers”).1–3 The first to appear, by Baas et al., included Kevin T. McVary, MD as a co-author. The article disclosed that Dr. McVary had … Read more

Research review: Alterations to penile and prostatic tissue associated with finasteride and dutasteride treatment

Simple summary: Numerous studies have shown that treatment with finasteride and dutasteride can change the size, tissue composition and function of the prostate and penis. In the prostate, treatment with finasteride or dutasteride is linked to: reduced size and weight; tissue atrophy; fewer blood microvessels; and decreases in substances involved in erectile function and maintenance … Read more

Adverse events affecting reproductive anatomy and sexual function in younger men who took finasteride

Summary This post documents adverse events (AEs) of finasteride affecting male reproductive anatomy and sexual function in men age 18–40, which were reported to US FDA and downloaded from the Federal Adverse Event Reporting System Public Dashboard. The data range is January 1, 2000 to December 31, 2020. This shows AEs assigned to categories which … Read more

The most-published researchers on adverse effects of finasteride for the treatment of hair loss

This post covers researchers who have published at least three papers on adverse effects of finasteride and 5-alpha reductase inhibitors when taken as a treatment for hair loss, typically by younger men. Collectively, this group has published more than 60 papers on this topic. Keep in mind these caveats: This list does not represent all … Read more

Paper: Differential Gene Expression in Post-Finasteride Syndrome Patients

By arrangement with the publisher, full text of the following paper is available: Howell S, Song W, Pastuszak A, Khera M. Differential Gene Expression in Post-Finasteride Syndrome Patients. J Sex Med. 2021;18(9):1479–1490. doi:10.1016/j.jsxm.2021.05.009. PMID: 34247957. Abstract Background An organic etiology underpinning post-finasteride syndrome, a constellation of persistent sexual, neuropsychiatric, and somatic symptoms reported by men … Read more