Special topics

See also: Related research by field, including endocrinology, sexual medicine, genetics, periodontology, pharmacology & biochemistry, psychiatry & neurology, and urology.


DNA repair mediated by androgens or androgen receptor

Casimiro MC, Di Sante G, Ju X. Cyclin D1 promotes androgen-dependent DNA damage repair in prostate cancer cells. Cancer Res. 2016 Jan 15. doi:10.1158/0008-5472.CAN-15-0999 • PubMed • PMC full text

Chen SR, Hao XX, Zhang Y. Androgen receptor in Sertoli cells regulates DNA double-strand break repair and chromosomal synapsis of spermatocytes partially through intercellular EGF-EGFR signaling. Oncotarget. 2016 Apr 5. doi:10.18632/oncotarget.7916 • PubMed • PMC full text

Goodwin JF, Schiewer MJ, Dean JL, et al. A hormone-DNA repair circuit governs the response to genotoxic insult. Cancer Discov. 2013 Nov. doi:10.1158/2159-8290.CD-13-0108 • PubMed • PMC full text

McCarthy, N. Understanding why. Nat Rev Cancer. 2013. doi:10.1038/nrc3615 • PubMed

Microbiome

Borgo F, Macandog AD, Diviccaro S, et al. Alterations of gut microbiota composition in post-finasteride patients: a pilot study. J Endocrinol Invest. 2021 Jun. doi:10.1007/s40618-020-01424-0. PubMedPMC full text

Diviccaro S, Giatti S, Borgo F, et al. Treatment of male rats with finasteride, an inhibitor of 5alpha-reductase enzyme, induces long-lasting effects on depressive-like behavior, hippocampal neurogenesis, neuroinflammation and gut microbiota composition. Psychoneuroendocrinology. 2019. doi:10.1016/j.psyneuen.2018.09.021 • PubMed

Liu J, Lai L, Lin J, et al. Ranitidine and finasteride inhibit the synthesis and release of trimethylamine N-oxide and mitigates its cardiovascular and renal damage through modulating gut microbiota. Int J Biol Sci. 2020 Jan 14. doi:10.7150/ijbs.40934PubMed