Related research
This bibliography consists of research that is not specifically about adverse effects of 5-alpha reductase inhibitors (5-ARIs), but could inform explanation, diagnosis or treatment of lasting dysfunctions after use of 5-ARIs. See also: Special topics
- Cancer
- Dermatology
- Endocrinology, andrology & sexual medicine
- Epidemiology & pharmacovigilance
- Genetics
- Geriatrics
- Neuroendocrinology
- Ophthalmology
- Periodontology
- Pharmacology & biochemistry
- Psychiatry & neurology
- Sports medicine
- Urology & prostate cancer
Cancer
See also Urology & prostate cancer
Orozco M, Valdez RA, Ramos L, Cabeza M, Segovia J, Romano MC. Dutasteride combined with androgen receptor antagonists inhibit glioblastoma U87 cell metabolism, proliferation, and invasion capacity: androgen regulation. Steroids. 2020 Dec. doi:10.1016/j.steroids.2020.108733 • PubMed
Dermatology
Babbush KM, Andriano TM, Cohen SR. Anti-androgen therapy in hidradenitis suppurativa: finasteride for females. Clin Exp Dermatol. 2021 Jul 14. doi:10.1111/ced.14847 • PubMed
Camacho FM, García-Hernández MJ, Fernández-Crehuet JL. Value of hormonal levels in patients with male androgenetic alopecia treated with finasteride: better response in patients under 26 years old. Br J Dermatol. 2008 May. doi:10.1111/j.1365-2133.2008.08509.x • PubMed
Hatanaka T, Lulic Z, Mefo T, Booth C, Harrison E, Ong G. Change in hair growth-related gene expression profile in human isolated hair follicles induced by 5-alpha reductase inhibitors – dutasteride and finasteride – in the presence of testosterone. Singapore Med J. 2022 Sep. doi:10.11622/smedj.2021080 • Full text via journal • PubMed
Karagaiah P, Daveluy S, Ortega-Loayza A, et al. Update on hormonal therapy in hidradenitis suppurativa. J Drugs Dermatol. 2023. doi:10.36849/JDD.6235 • PubMed
Keene S, Goren A. Therapeutic hotline. Genetic variations in the androgen receptor gene and finasteride response in women with androgenetic alopecia mediated by epigenetics. Dermatol Ther. 2011. doi:10.1111/j.1529-8019.2011.01407.x • PubMed
Moghetti P, Castello R, Magnani CM, et al. Clinical and hormonal effects of the 5 alpha-reductase inhibitor finasteride in idiopathic hirsutism. J Clin Endocrinol Metab. 1994. doi:10.1210/jcem.79.4.7962284 • PubMed
Motofei IG, Rowland DL, Baconi DL, et al. Androgenetic alopecia; drug safety and therapeutic strategies. Expert Opin Drug Saf. 2018. doi:10.1080/14740338.2018.1430765 • PubMed
[Comment] Ong G, Manyak M, Lulic Z. Letter to the editor: Androgenetic alopecia; drug safety and therapeutic strategies. Expert Opin Drug Saf. 2018 Jun. doi:10.1080/14740338.2018.1470744 • PubMed
[Comment] Motofei IG, Rowland DL. Response to the letter to the editor; Androgenetic alopecia; drug safety and therapeutic strategies. Expert Opin Drug Saf. 2018 Jun. doi:10.1080/14740338.2018.1470749 • PubMed
Nguyen QH, Chen T, Wang X, Chen Y, Chien P. Finasteride inhibits 5 alpha-reductase activity in human dermal fibroblasts: prediction of its therapeutic application in androgen-related skin diseases. Int J Dermatol. 1995 Oct. doi:10.1111/j.1365-4362.1995.tb04663.x • PubMed
Sawaya ME, Blume-Peytavi U, Mullins DL, et al. Effects of finasteride on apoptosis and regulation of the human hair cycle. J Cutan Med Surg. 2002 Jan-Feb. doi:10.1007/s10227-001-0024-y • PubMed
Seo JO, Yumnam S, Jeong KW, Kim SY. Finasteride inhibits melanogenesis through regulation of the adenylate cyclase in melanocytes and melanoma cells. Arch Pharm Res. 2018 Mar. doi:10.1007/s12272-018-1002-x • PubMed • PMC full text
[⚠️ Funded by an “educational grant” from Merck] Stough D, Stenn K, Haber R, et al. Psychological effect, pathophysiology, and management of androgenetic alopecia in men. Mayo Clin Proc. 2005. doi:10.4065/80.10.1316 • PubMed
Wakisaka N, Taira Y, Ishikawa M, et al. Effectiveness of finasteride on patients with male pattern baldness who have different androgen receptor gene polymorphism. J Investig Dermatol Symp Proc. 2005 Dec. doi:10.1111/j.0022-202X.2005.10123.x • PubMed
Yamazaki M, Sato A, Toyoshima KE, et al. Polymorphic CAG repeat numbers in the androgen receptor gene of female pattern hair loss patients. J Dermatol. 2011 Jul. doi:10.1111/j.1346-8138.2010.01060.x • PubMed
Endocrinology, andrology and sexual medicine
Anawalt BD. Is dihydrotestosterone a classic hormone? Endocr Rev. 2017 Jun 1. doi:10.1210/er.2017-00091 • PubMed
Baker RC, Bergeson RL, Yi YA, Ward EE, Morey AF. Dutasteride in the long-term management of stuttering priapism. Transl Androl Urol. 2020 Feb. doi:10.21037/tau.2019.07.15 • PubMed • PMC full text
Bissegger S, Langlois VS. Androgens modulate gene expression and specific DNA methylation pattern of steroid 5α-reductases in the frog Silurana tropicalis. Gen Comp Endocrinol. 2016. doi:10.1016/j.ygcen.2016.03.021 • PubMed
Boehmer AL, Brinkmann AO, Nijman RM, et al. Phenotypic variation in a family with partial androgen insensitivity syndrome explained by differences in 5alpha dihydrotestosterone availability. J Clin Endocrinol Metab. 2001. doi:10.1210/jcem.86.3.7333 • PubMed
Borst SE, Yarrow JF, Conover CF, et al. Musculoskeletal and prostate effects of combined testosterone and finasteride administration in older hypogonadal men: a randomized, controlled trial. Am J Physiol Endocrinol Metab. 2014 Feb 15. doi:10.1152/ajpendo.00592.2013 • PubMed • PMC full text
Borst SE, Yarrow JF, Fernandez C, et al. Cognitive effects of testosterone and finasteride administration in older hypogonadal men. Clin Interv Aging. 2014 Aug 12. doi:10.2147/CIA.S61760 • PubMed • PMC full text
Chávez B, Ramos L, García-Becerra R, Vilchis F. Hamster SRD5A3 lacks steroid 5α-reductase activity in vitro. Steroids. 2015;94:41–50. doi:10.1016/j.steroids.2014.11.005 • PubMed
Huh JS, Chung BH, Hong CH, et al. The effects of testosterone replacement on penile structure and erectile function after long-term castration in adult male rats. Int J Impot Res. 2018. doi:10.1038/s41443-017-0010-6 • PubMed
Karakas SE, Surampudi P. New biomarkers to evaluate hyperandrogenemic women and hypogonadal men. Adv Clin Chem. 2018. doi:10.1016/bs.acc.2018.06.001 • PubMed
Lugg JA, Rajfer J, González-Cadavid NF. Dihydrotestosterone is the active androgen in the maintenance of nitric oxide-mediated penile erection in the rat. Endocrinology. 1995 Apr;136(4):1495-501. doi:10.1210/endo.136.4.7534702 • PubMed
Moghetti P, Castello R, Magnani CM, et al. Clinical and hormonal effects of the 5 alpha-reductase inhibitor finasteride in idiopathic hirsutism. J Clin Endocrinol Metab. 1994 Oct;79(4):1115-21. doi:10.1210/jcem.79.4.7962284 • PubMed
Rachid-Filho D, Cavalcanti AG, Favorito LA, Costa WS, Sampaio FJ. Treatment of recurrent priapism in sickle cell anemia with finasteride: a new approach. Urology. 2009 Nov. doi:10.1016/j.urology.2009.04.071 • PubMed
Sansone A, Kliesch S, Dugas M, et al. Serum concentrations of dihydrotestosterone are associated with symptoms of hypogonadism in biochemically eugonadal men. J Endocrinol Invest. 2021. doi:10.1007/s40618-021-01561-0 • PubMed • PMC full text
Sasaki G, Ishii T, Hori N, Amano N, Homma K, Sato S, Hasegawa T. Effects of pre- and post-pubertal dihydrotestosterone treatment on penile length in 5α-reductase type 2 deficiency. Endocr J. 2019 Sep 28. doi:10.1507/endocrj.EJ19-0111 • PubMed
Schulster M, Bernie AM, Ramasamy R. The role of estradiol in male reproductive function. Asian J Androl. 2016 May-Jun. doi:10.4103/1008-682X.173932 • PubMed • PMC full text
Swerdloff RS, Dudley RE, Page ST, Wang C, Salameh WA. Dihydrotestosterone: biochemistry, physiology, and clinical implications of elevated blood levels. Endocr Rev. 2017 Jun 1. doi:10.1210/er.2016-1067 • PubMed • PMC full text
Tut TG, Ghadessy FJ, Trifiro MA, Pinsky L, Yong EL. Long polyglutamine tracts in the androgen receptor are associated with reduced trans-activation, impaired sperm production, and male infertility. J Clin Endocrinol Metab. 1997 Nov. doi:10.1210/jcem.82.11.4385 • PubMed
Yamana K, Labrie F, Luu-The V. Human type 3 5α-reductase is expressed in peripheral tissues at higher levels than types 1 and 2 and its activity is potently inhibited by finasteride and dutasteride. Horm Mol Biol Clin Investig. 2010 Aug 1. doi:10.1515/HMBCI.2010.035 • PubMed
[⚠️ All authors have a relationship to telehealth company Keeps, as Medical Director, employee of parent company or medical advisor] Young PC, Mahajan C, Shapiro J, Tosti A. Digital health platforms expand access and improve care for male androgenetic alopecia. Int J Dermatol. 2023. doi:10.1111/ijd.16452 • PubMed
Epidemiology & pharmacovigilance
Souverein PC, Herings RM, De la Rosette JJ, Man in ‘t Veld AJ, Farmer RD, Leufkens HG. Evaluating adverse cardiovascular effects of drug treatment for benign prostatic hyperplasia (BPH): methodological considerations. J Clin Epidemiol. 2001. doi:10.1016/s0895-4356(00)00327-9 • PubMed
Genetics
See also: Androgen receptors and Research by field: Genetics
Bissegger S, Langlois VS. Androgens modulate gene expression and specific DNA methylation pattern of steroid 5α-reductases in the frog Silurana tropicalis. Gen Comp Endocrinol. 2016. doi:10.1016/j.ygcen.2016.03.021 • PubMed [Study does not involve finasteride]
Buccitelli C, Selbach M. mRNAs, proteins and the emerging principles of gene expression control. Nat Rev Genet. 2020 Oct. doi:10.1038/s41576-020-0258-4 • PubMed
da Cruz GK, Martins MIM, Antunes FTT, et al. Evaluation of the efficacy and toxicity of oral and topical pumpkin oil on the hair growth of mice. Acta Histochem. 2022 Apr 18. doi:10.1016/j.acthis.2022.151894 • PubMed. [DNA damage in minoxidil treatment group]
Ellis JA, Stebbing M, Harrap SB. Polymorphism of the androgen receptor gene is associated with male pattern baldness. J Invest Dermatol. 2001 Mar. doi:10.1046/j.1523-1747.2001.01261.x • PubMed
Grigorova M, Punab M, Kahre T, et al. The number of CAG and GGN triplet repeats in the Androgen Receptor gene exert combinatorial effect on hormonal and sperm parameters in young men. Andrology. 2017 May. doi:10.1111/andr.12344 • PubMed
Hatanaka T, Lulic Z, Mefo T, Booth C, Harrison E, Ong G. Change in hair growth-related gene expression profile in human isolated hair follicles induced by 5-alpha reductase inhibitors – dutasteride and finasteride – in the presence of testosterone. Singapore Med J. 2022 Sep. doi:10.11622/smedj.2021080 • Full text via journal • PubMed
Katharopoulos E, Sauter K, Pandey AV, Flück CE. In silico and functional studies reveal novel loss-of-function variants of SRD5A2, but no variants explaining excess 5α-reductase activity. J Steroid Biochem Mol Biol. 2019 Jun. doi:10.1016/j.jsbmb.2019.01.017 • PubMed
Levy-Nissenbaum E, Bar-Natan M, Frydman M, Pras E. Confirmation of the association between male pattern baldness and the androgen receptor gene. Eur J Dermatol. 2005 Sep-Oct. PubMed
Lin ZM, Fan DD, Jin S, Liu ZL, Niu YN. Methylated CpG dinucleotides in the 5-α reductase 2 gene may explain finasteride resistance in benign prostatic enlargement patients. Asian J Androl. 2020 Nov 20. doi:10.4103/aja.aja_63_20 • PubMed
Lolli F, Pallotti F, Rossi A, Fortuna MC, Caro G, Lenzi A, Sansone A, Lombardo F. Androgenetic alopecia: a review. Endocrine. 2017 Jul. doi:10.1007/s12020-017-1280-y • PubMed
Medline Plus: SRD5A2 gene.
Samtani R, Bajpai M, Ghosh PK, Saraswathy KN. A49T, R227Q and TA repeat polymorphism of steroid 5 alpha-reductase type II gene and Hypospadias risk in North Indian children. Meta Gene. 2014 Dec 11. doi:10.1016/j.mgene.2014.11.003 • PubMed
Sasaki G, Ishii T, Hori N, Amano N, Homma K, Sato S, Hasegawa T. Effects of pre- and post-pubertal dihydrotestosterone treatment on penile length in 5α-reductase type 2 deficiency. Endocr J. 2019 Sep 28. doi:10.1507/endocrj.EJ19-0111 • PubMed
Stiles AR, Russell DW. SRD5A3: A surprising role in glycosylation. Cell. 2010 Jul 23. doi:10.1016/j.cell.2010.07.003 • 20655462 • PMC full text
Thigpen AE, Silver RI, Guileyardo JM, Casey ML, McConnell JD, Russell DW. Tissue distribution and ontogeny of steroid 5 alpha-reductase isozyme expression. J Clin Invest. 1993 Aug;92(2):903-10. doi:10.1172/JCI116665 • PubMed • PMC full text
Tirabassi G, Cignarelli A, Perrini S, et al. Influence of CAG repeat polymorphism on the targets of testosterone action. Int J Endocrinol. 2015. doi:10.1155/2015/298107 • PubMed • Full text
Zimmermann N, Zschocke J, Perisic T, Yu S, Holsboer F, Rein T. Antidepressants inhibit DNA methyltransferase 1 through reducing G9a levels. Biochem J. 2012. doi:10.1042/BJ20120674 • PubMed
Geriatrics
Na HR, Cho ST, Lee JS, Kim S. P4‐324: Finasteride treatment of hypersexuality associated with vascular dementia and underlying benign prostate hyperplasia. Alzheimer’s & Dementia. 2008;4(4S Part 24):T767. doi:10.1016/j.jalz.2008.05.2394
Borst SE, Yarrow JF, Conover CF, et al. Musculoskeletal and prostate effects of combined testosterone and finasteride administration in older hypogonadal men: a randomized, controlled trial. Am J Physiol Endocrinol Metab. 2014 Feb 15. doi:10.1152/ajpendo.00592.2013 • PubMed • PMC full text
Borst SE, Yarrow JF, Fernandez C, et al. Cognitive effects of testosterone and finasteride administration in older hypogonadal men. Clin Interv Aging. 2014 Aug 12. doi:10.2147/CIA.S61760 • PubMed • PMC full text
Na HR, Lee JW, Park SM, Ko SB, Kim S, Cho ST. Inappropriate sexual behaviors in patients with vascular dementia: possible response to finasteride. J Am Geriatr Soc. 2009 Nov. doi:10.1111/j.1532-5415.2009.02536.x • PubMed
Neuroendocrinology
Agis-Balboa RC, Guidotti A, Pinna G. 5α-reductase type I expression is downregulated in the prefrontal cortex/Brodmann’s area 9 (BA9) of depressed patients. Psychopharmacology (Berl). 2014 Sep. doi:10.1007/s00213-014-3567-5 • PubMed • PMC full text
Bali A, Jaggi AS. Multifunctional aspects of allopregnanolone in stress and related disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jan 3. doi:10.1016/j.pnpbp.2013.09.005 • PubMed
Bortolato M, Devoto P, Roncada P, et al. Isolation rearing-induced reduction of brain 5α-reductase expression: relevance to dopaminergic impairments. Neuropharmacology. 2011 Jun. doi:10.1016/j.neuropharm.2011.01.013 • PubMed
Chen S, Gao L, Li X, Ye Y. Allopregnanolone in mood disorders: mechanism and therapeutic development. Pharmacol Res. 2021 May 18. doi:10.1016/j.phrs.2021.105682 • PubMed
Christian CA. Nucleus-specific modulation of phasic and tonic inhibition by endogenous neurosteroidogenesis in the murine thalamus. Synapse. 2020 May. doi:10.1002/syn.22144 • PubMed • PMC full text
Duong P, Tenkorang MAA, Trieu J, McCuiston C, Rybalchenko N, Cunningham RL. Neuroprotective and neurotoxic outcomes of androgens and estrogens in an oxidative stress environment. Biol Sex Differ. 2020 Mar 29. doi:10.1186/s13293-020-0283-1 • PubMed • PMC full text
Frau R, Bini V, Pes R, et al. Inhibition of 17α-hydroxylase/C17,20 lyase reduces gating deficits consequent to dopaminergic activation. Psychoneuroendocrinology. 2014 Jan. doi:10.1016/j.psyneuen.2013.09.014 • PubMed • PMC full text
Frau R, Mosher LJ, Bini V, et al. The neurosteroidogenic enzyme 5α-reductase modulates the role of D1 dopamine receptors in rat sensorimotor gating. Psychoneuroendocrinology. 2016. doi:10.1016/j.psyneuen.2015.09.014 • PubMed
Giatti S, Diviccaro S, Falvo E, Miguel Garcia-Segura L, Melcangi RC. Physiopathological role of the enzymatic complex 5α-reductase and 3α/β-hydroxysteroid oxidoreductase in the generation of progesterone and testosterone neuroactive metabolites. Front Neuroendocrinol. 2020. doi:10.1016/j.yfrne.2020.100836 • PubMed
Giatti S, Diviccaro S, Serafini MM, et al. Sex differences in steroid levels and steroidogenesis in the nervous system: Physiopathological role. Front Neuroendocrinol. 2020. doi:10.1016/j.yfrne.2019.100804 • PubMed
Giatti S, Garcia-Segura LM, Barreto GE, Melcangi RC. Neuroactive steroids, neurosteroidogenesis and sex. Prog Neurobiol. 2019. doi:10.1016/j.pneurobio.2018.06.007 • PubMed
Hill RA, Pompolo S, Jones ME, Simpson ER, Boon WC. Estrogen deficiency leads to apoptosis in dopaminergic neurons in the medial preoptic area and arcuate nucleus of male mice. Mol Cell Neurosci. 2004 Dec. doi:10.1016/j.mcn.2004.04.012 • PubMed
Kalakh S, Mouihate A. Enhanced remyelination during late pregnancy: involvement of the GABAergic system. Sci Rep. 2019 May 22. doi:10.1038/s41598-019-44050-4 • PubMed • PMC full text
Marciniak E, Młotkowska P, Roszkowicz-Ostrowska K, Ciska E, Misztal T. Involvement of neurosteroids in the control of prolactin secretion in sheep under basal, stressful and pregnancy conditions. Theriogenology. 2022. doi:10.1016/j.theriogenology.2022.08.013 • PubMed
Melcangi RC, Panzica GC. Allopregnanolone: state of the art. Prog Neurobiol. 2014 Feb. doi:10.1016/j.pneurobio.2013.09.005 • PubMed
Melcangi RC, Riva MA, Fumagalli F, Magnaghi V, Racagni G, Martini L. Effect of progesterone, testosterone and their 5 alpha-reduced metabolites on GFAP gene expression in type 1 astrocytes. Brain Res. 1996. doi:10.1016/0006-8993(95)01302-4 • PubMed
Meng Z, Rowlett JK. Self-administration of progesterone and synthetic neuroactive steroids by male rhesus monkeys. Drug Alcohol Depend. 2016 Aug 1. doi:10.1016/j.drugalcdep.2016.05.029 • PubMed • PMC full text
Misztal T, Młotkowska P, Marciniak E, Roszkowicz-Ostrowska K, Misztal A. Involvement of neurosteroids in the control of hypothalamic-pituitary-adrenal axis activity in pregnant sheep under basal and stressful conditions. Theriogenology. 2021 Aug 20. doi:10.1016/j.theriogenology.2021.08.026 • PubMed
Nasiri M, Nikolaou N, Parajes S, et al. 5α-reductase type 2 regulates glucocorticoid action and metabolic phenotype in human hepatocytes. Endocrinology. 2015 Aug. doi:10.1210/en.2015-1149 • PubMed • PMC full text
Pinacho-Garcia LM, Valdez RA, Navarrete A, Cabeza M, Segovia J, Romano MC. The effect of finasteride and dutasteride on the synthesis of neurosteroids by glioblastoma cells. Steroids. 2020 Mar. doi:10.1016/j.steroids.2019.108556 • PubMed
Pinna G. Allopregnanolone, the neuromodulator turned therapeutic agent: Thank you, next? Front Endocrinol (Lausanne). 2020 May 14. doi:10.3389/fendo.2020.00236 • PubMed • PMC full text
Samba Reddy D, Ramanathan G. Finasteride inhibits the disease-modifying activity of progesterone in the hippocampus kindling model of epileptogenesis. Epilepsy Behav. 2012 Sep. doi:10.1016/j.yebeh.2012.05.024 • PubMed
Scarduzio M, Panichi R, Pettorossi VE, Grassi S. Synaptic long-term potentiation and depression in the rat medial vestibular nuclei depend on neural activation of estrogenic and androgenic signals. PLoS One. 2013 Nov 12. doi:10.1371/journal.pone.0080792 • PubMed • PMC full text
Shen ZJ, Lu YL, Chen ZD, Chen F, Chen Z. Effects of androgen and ageing on gene expression of vasoactive intestinal polypeptide in rat corpus cavernosum. BJU Int. 2000 Jul. doi:10.1046/j.1464-410x.2000.00721.x • PubMed
Sun YH, Gao X, Tang YJ, Xu CL, Wang LH. Androgens induce increases in intracellular calcium via a G protein-coupled receptor in LNCaP prostate cancer cells. J Androl. 2006 Sep-Oct. doi:10.2164/jandrol.106.000554 • PubMed
Tesone AJ, Regueira E, Canosa LF, Ceballos NR. 5α-Reductase, an enzyme regulating glucocorticoid action in the testis of Rhinella arenarum (Amphibia: Anura). Gen Comp Endocrinol. 2012 May 1. doi:10.1016/j.ygcen.2012.01.004 • PubMed
Tokuda K, Izumi Y, Zorumski CF. Ethanol enhances neurosteroidogenesis in hippocampal pyramidal neurons by paradoxical NMDA receptor activation. J Neurosci. 2011 Jul 6. doi:10.1523/JNEUROSCI.1660-11.2011 • PubMed • PMC full text
van Luijtelaar G, Budziszewska B, Tetich M, Lasoń W. Finasteride inhibits the progesterone-induced spike-wave discharges in a genetic model of absence epilepsy. Pharmacol Biochem Behav. 2003 Jul. doi:10.1016/s0091-3057(03)00162-x • PubMed
Ophthalmology
See also: Research: adverse effects on eyes & visual function
Fusi-Rubiano W, Saedon H, Patel V, Yang YC. Oral medications for central serous chorioretinopathy: a literature review. Eye (Lond). 2020 May. DOI • PubMed • PMC full text
Gülkaş S, Şahin Ö. Current therapeutic approaches to chronic central serous chorioretinopathy. Turk J Ophthalmol. 2019 Feb 28. DOI • PubMed • PMC full text
Moisseiev E, Holmes AJ, Moshiri A, Morse LS. Finasteride is effective for the treatment of central serous chorioretinopathy. Eye (Lond). 2016 Jun. DOI • PubMed • PMC full text
Rocha EM, Wickham LA, da Silveira LA, et al. Identification of androgen receptor protein and 5alpha-reductase mRNA in human ocular tissues. Br J Ophthalmol. 2000. doi:10.1136/bjo.84.1.76 • PubMed • PMC full text
Periodontology
Kasasa SC, Soory M. The combined effects of TGF-beta, IGF and PDGF on 5alpha-reductase activity on androgen substrates in human gingival tissue. Inflammopharmacology. 1998. doi:10.1007/s10787-998-0021-5 • PubMed
Southren AL, Rappaport SC, Gordon GG, Vittek J. Specific 5 alpha-dihydrotestosterone receptors in human gingiva. J Clin Endocrinol Metab. 1978. doi:10.1210/jcem-47-6-1378 • PubMed
Pharmacology & biochemistry
Aggarwal S, Thareja S, Verma A, Bhardwaj TR, Kumar M. An overview on 5alpha-reductase inhibitors. Steroids. 2010. doi:10.1016/j.steroids.2009.10.005 • PubMed
Agis-Balboa RC, Guidotti A, Pinna G. 5α-reductase type I expression is downregulated in the prefrontal cortex/Brodmann’s area 9 (BA9) of depressed patients. Psychopharmacology (Berl). 2014 Sep. doi:10.1007/s00213-014-3567-5 • PubMed • PMC full text
Bortolato M, Frau R, Orrù M, et al. Antipsychotic-like properties of 5-alpha-reductase inhibitors. Neuropsychopharmacology. 2008 Dec. doi:10.1038/npp.2008.39 • PubMed
Bosse GD, Cadeddu R, Floris G, et al. The 5α-reductase inhibitor finasteride reduces opioid self-administration in animal models of opioid use disorder. J Clin Invest. 2021 Apr 13. doi:10.1172/JCI143990 • PubMed
Bull HG, Garcia-Calvo M, Andersson S, et al. Mechanism-based inhibition of human steroid 5α-reductase by finasteride: enzyme-catalyzed formation of NADP−dihydrofinasteride, a potent bisubstrate analog inhibitor. Journal of the American Chemical Society. 1996. doi:10.1021/ja953069t
Chávez B, Ramos L, García-Becerra R, Vilchis F. Hamster SRD5A3 lacks steroid 5α-reductase activity in vitro. Steroids. 2015;94:41–50. doi:10.1016/j.steroids.2014.11.005 • PubMed
Devoto P, Frau R, Bini V, et al. Inhibition of 5α-reductase in the nucleus accumbens counters sensorimotor gating deficits induced by dopaminergic activation. Psychoneuroendocrinology. 2012 Oct. doi:10.1016/j.psyneuen.2011.09.018 • PubMed • PMC full text
Eckstein M, Rea M, Fondufe-Mittendorf YN. Transient and permanent changes in DNA methylation patterns in inorganic arsenic-mediated epithelial-to-mesenchymal transition. Toxicol Appl Pharmacol. 2017 Sep 15. doi:10.1016/j.taap.2017.03.017 • PubMed • PMC full text
Ellsworth KP, Azzolina BA, Cimis G, Bull HG, Harris GS. Cloning, expression and characterization of rhesus macaque types 1 and 2 5alpha-reductase: evidence for mechanism-based inhibition by finasteride. J Steroid Biochem Mol Biol. 1998 Sep. doi:10.1016/s0960-0760(98)00059-4 • PubMed
Finn DA, Long SL, Tanchuck MA, Crabbe JC. Interaction of chronic ethanol exposure and finasteride: sex and strain differences. Pharmacol Biochem Behav. 2004 Jul. doi:10.1016/j.pbb.2004.04.016 • PubMed
Floris G, Scheggi S, Pes R, Bortolato M. The steroidogenic inhibitor finasteride reverses pramipexole-induced alterations in probability discounting. Brain Res Bull. 2022 Apr. doi:10.1016/j.brainresbull.2022.01.020 • PubMed
Fouad Mansour M, Pelletier M, Tchernof A. Characterization of 5α-reductase activity and isoenzymes in human abdominal adipose tissues. J Steroid Biochem Mol Biol. 2016 Jul. doi:10.1016/j.jsbmb.2016.02.003 • PubMed
Frau R, Pillolla G, Bini V, Tambaro S, Devoto P, Bortolato M. Inhibition of 5α-reductase attenuates behavioral effects of D1-, but not D2-like receptor agonists in C57BL/6 mice. Psychoneuroendocrinology. 2013 Apr. doi:10.1016/j.psyneuen.2012.07.014 • PubMed
Gorin-Meyer RE, Wiren KM, Tanchuck MA, Long SL, Yoneyama N, Finn DA. Sex differences in the effect of finasteride on acute ethanol withdrawal severity in C57BL/6J and DBA/2J mice. Neuroscience. 2007. doi:10.1016/j.neuroscience.2007.02.051 • PubMed • PMC full text
Han Y, Zhuang Q, Sun B, et al. Crystal structure of steroid reductase SRD5A reveals conserved steroid reduction mechanism. Nat Commun. 2021 Jan 19. doi:10.1038/s41467-020-20675-2 • PubMed
Ishii Y, Mukoyama H, Hata S. Metabolism of finasteride in rat hepatic microsomes: age and sex differences and effects of P450 inducers. Xenobiotica. 1994 Sep. doi:10.3109/00498259409043285 • PubMed
Khantham C, Yooin W, Sringarm K, et al. Effects on steroid 5-alpha reductase gene expression of Thai rice bran extracts and molecular dynamics study on SRD5A2. Biology (Basel). 2021 Apr 11. doi:10.3390/biology10040319 • PubMed
Kim D, Cho H, Eggers R, Kim SK, Ryu CS, Kim YJ. Development of a liquid chromatography/mass spectrometry-based inhibition assay for the screening of steroid 5-α reductase in human and fish cell lines. Molecules. 2021 Feb 8. doi:10.3390/molecules26040893 • PubMed
Kim HJ, Kim TJ, Kim YG, Seong C, Cho JH, Kim W, Lee KH, Kim DY. Antioxidant and antiproliferative activity of finasteride against glioblastoma cells. Pharmaceutics. 2021 Sep 6. doi:10.3390/pharmaceutics13091410 • PubMed
Koukoulis GN, Filiponi M, Gougoura S, Befani C, Liakos P, Bargiota Α. Testosterone and dihydrotestosterone modulate the redox homeostasis of endothelium. Cell Biol Int. 2022 Apr. doi:10.1002/cbin.11768 • PubMed
Kudryashov NV, Ivanova EA, Kalinina TS, et al. Antiexudative effects of finasteride and a new pyrazolo[c]pyridine derivative GIZh-72 in acetic acid-induced experimental peritonitis. Bull Exp Biol Med. 2020 Feb. doi:10.1007/s10517-020-04730-y • PubMed
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