Isotretinoin (Accutane / Roaccutane)

See also: Epigenetics of adverse drug reactions

Becker E, Bengs S, Aluri S, et al. Large-scale integrative analysis of epigenetic modifications induced by isotretinoin, doxycycline and metronidazole in murine colonic intestinal epithelial cells. Epigenomes. 2017. doi:10.3390/epigenomes1030024

Boudou P, Soliman H, Chivot M, et al. Effect of oral isotretinoin treatment on skin androgen receptor levels in male acneic patients. J Clin Endocrinol Metab. 1995. doi:10.1210/jcem.80.4.7714084PubMed

Bremner JD. Isotretinoin and neuropsychiatric side effects: continued vigilance is needed. J Affect Disord Rep. 2021. doi:10.1016/j.jadr.2021.100230 • PubMed • PMC full text

Bremner JD, Fani N, Ashraf A, et al. Functional brain imaging alterations in acne patients treated with isotretinoin. Am J Psychiatry. 2005. doi:10.1176/appi.ajp.162.5.983PubMed. Erratum in: Am J Psychiatry. 2008 Dec.

Bremner JD, Shearer KD, McCaffery PJ. Retinoic acid and affective disorders: the evidence for an association. J Clin Psychiatry. 2012. doi:10.4088/JCP.10r05993 • PubMed • PMC full text

Coleman R, MacDonald D. Effects of isotretinoin on male reproductive system. Lancet. 1994. doi:10.1016/s0140-6736(94)92803-7PubMed

Healy D, Bahrick A, Bak M, et al. Diagnostic criteria for enduring sexual dysfunction after treatment with antidepressants, finasteride and isotretinoin. Int J Risk Saf Med. 2021. doi:10.3233/JRS-210023 • PubMed • PMC full text

Healy D, Le Noury J, Mangin D. Enduring sexual dysfunction after treatment with antidepressants, 5α-reductase inhibitors and isotretinoin: 300 cases. Int J Risk Saf Med. 2018. doi:10.3233/JRS-180744 • PubMed

Hogan C, Le Noury J, Healy D, Mangin D. One hundred and twenty cases of enduring sexual dysfunction following treatment. Int J Risk Saf Med. 2014. doi:10.3233/JRS-140617 • PubMed

Jiang Y, Chen H, Han L, Xie X, Zheng Y, Lai W. Altered gene expression in acne vulgaris patients treated by oral isotretinoin: a preliminary study. Pharmgenomics Pers Med. 2020. doi:10.2147/PGPM.S250969. PubMedPMC full text

Melnik BC. Apoptosis may explain the pharmacological mode of action and adverse effects of isotretinoin, including teratogenicity. Acta Derm Venereol. 2017. doi:10.2340/00015555-2535PubMed

Nelson AM, Zhao W, Gilliland KL, Zaenglein AL, Liu W, Thiboutot DM. Early gene changes induced by isotretinoin in the skin provide clues to its mechanism of action. Dermatoendocrinol. 2009. doi:10.4161/derm.1.2.8107PubMedPMC full text

Nelson AM, Zhao W, Gilliland KL, Zaenglein AL, Liu W, Thiboutot DM. Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009. doi:10.4161/derm.1.3.8258PubMedPMC full text

Tirado Sánchez A, León Dorantes G. Disfunción eréctil durante el tratamiento con isotretinoína [Erectile dysfunction during isotretinoin therapy]. Actas Urol Esp. 2005. Spanish. doi:10.1016/s0210-4806(05)73379-9 • PubMed

U.K. Commission on Human Medicines. Report of the Commission on Human Medicines Isotretinoin Expert Working Group. United Kingdom: Medicines and Healthcare products Regulatory Agency; 2023.