RESEARCH

Isotretinoin

See also: Epigenetics of adverse drug reactions

Becker E, Bengs S, Aluri S, et al. Large-scale integrative analysis of epigenetic modifications induced by isotretinoin, doxycycline and metronidazole in murine colonic intestinal epithelial cells. Epigenomes. 2017. doi:10.3390/epigenomes1030024

Boudou P, Soliman H, Chivot M, et al. Effect of oral isotretinoin treatment on skin androgen receptor levels in male acneic patients. J Clin Endocrinol Metab. 1995. doi:10.1210/jcem.80.4.7714084 • PubMed

Coleman R, MacDonald D. Effects of isotretinoin on male reproductive system. Lancet. 1994. doi:10.1016/s0140-6736(94)92803-7 • PubMed

Healy D, Bahrick A, Bak M, et al. Diagnostic criteria for enduring sexual dysfunction after treatment with antidepressants, finasteride and isotretinoin. Int J Risk Saf Med. 2021. doi:10.3233/JRS-210023 • PubMed • PMC full text

Healy D, Le Noury J, Mangin D. Enduring sexual dysfunction after treatment with antidepressants, 5α-reductase inhibitors and isotretinoin: 300 cases. Int J Risk Saf Med. 2018. doi:10.3233/JRS-180744 • PubMed

Hogan C, Le Noury J, Healy D, Mangin D. One hundred and twenty cases of enduring sexual dysfunction following treatment. Int J Risk Saf Med. 2014. doi:10.3233/JRS-140617 • PubMed

Jiang Y, Chen H, Han L, Xie X, Zheng Y, Lai W. Altered gene expression in acne vulgaris patients treated by oral isotretinoin: a preliminary study. Pharmgenomics Pers Med. 2020. doi:10.2147/PGPM.S250969. PubMed • PMC full text

Melnik BC. Apoptosis may explain the pharmacological mode of action and adverse effects of isotretinoin, including teratogenicity. Acta Derm Venereol. 2017. doi:10.2340/00015555-2535 • PubMed

Nelson AM, Zhao W, Gilliland KL, Zaenglein AL, Liu W, Thiboutot DM. Early gene changes induced by isotretinoin in the skin provide clues to its mechanism of action. Dermatoendocrinol. 2009. doi:10.4161/derm.1.2.8107 • PubMed • PMC full text

Nelson AM, Zhao W, Gilliland KL, Zaenglein AL, Liu W, Thiboutot DM. Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009. doi:10.4161/derm.1.3.8258 • PubMed • PMC full text

Tirado Sánchez A, León Dorantes G. Disfunción eréctil durante el tratamiento con isotretinoína [Erectile dysfunction during isotretinoin therapy]. Actas Urol Esp. 2005. Spanish. doi:10.1016/s0210-4806(05)73379-9 • PubMed