Altered expression of SRD5A2 gene

IN BRIEF: The gene SRD5A2 expresses enzyme 5-alpha reductase type 2. This enzyme is inhibited by finasteride and dutasteride (but see differences in pharmacology). Organs and tissues with higher SRD5A2 expression are expected to have a greater response to the drug’s inhibitory action. SRD5A2 expression is elevated in the male reproductive system, liver and lung (see chart) as well as the brain. Castelli et al. (2013) found evidence of the enzyme in most brain regions, including “critical regions for behavioral regulation.” A mutation of SRD5A2 causes 5-alpha reductase deficiency, a disorder of sexual development.

Expression of SRD5A2 gene by tissue type. There was significant expression of SRD5A2 in liver, prostate, bladder, testis and lung. Source: NCBI Gene

See also: Related research: Genetics


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