Research on altered expression of SRD5A2 gene

Expression of SRD5A2 gene by tissue type. There was significant expression of SRD5A2 in liver, prostate, bladder, testis and lung. Source: NCBI Gene

See also: Related research: Genetics

Papers appear in reverse chronological order.

2018–present

Jin R, Forbes C, Miller NL, et al. Glucocorticoids are induced while dihydrotestosterone levels are suppressed in 5-alpha reductase inhibitor treated human benign prostate hyperplasia patients. Prostate. 2022. doi:10.1002/pros.24410PubMed

Lin ZM, Fan DD, Jin S, Liu ZL, Niu YN. Methylated CpG dinucleotides in the 5-α reductase 2 gene may explain finasteride resistance in benign prostatic enlargement patients. Asian J Androl. 2021. doi:10.4103/aja.aja_63_20PubMed • PMC full text

Wang Z, Deng T, Long X, et al. Methylation of SRD5A2 promoter predicts a better outcome for castration-resistant prostate cancer patients undergoing androgen deprivation therapy. PLoS One. 2020. doi:10.1371/journal.pone.0229754PubMed• PMC full text

Xiao Q, Wang L, Supekar S, et al. Structure of human steroid 5α-reductase 2 with anti-androgen drug finasteride. Res Sq [Preprint]. 2020. doi:10.21203/rs.3.rs-40159/v1PubMed • PMC full text

Xue B, Wu S, Sharkey C, et al. Obesity-associated inflammation induces androgenic to estrogenic switch in the prostate gland. Prostate Cancer Prostatic Dis. 2020 Sep. doi:10.1038/s41391-020-0208-4 • PubMed • PMC full text

Melcangi RC, Casarini L, Marino M, et al. Altered methylation pattern of the SRD5A2 gene in the cerebrospinal fluid of post-finasteride patients: a pilot study. Endocrine Connections. 2019. doi:10.1530/EC-19-0199PubMed • PMC full text

2011–2017

Wang Z, Hu L, Salari K, et al. Androgenic to oestrogenic switch in the human adult prostate gland is regulated by epigenetic silencing of steroid 5α-reductase 2. J Pathol. 2017. doi:10.1002/path.4985PubMed • PMC full text

Basaria S, Jasuja R, Huang G, et al. Characteristics of men who report persistent sexual symptoms after finasteride use for hair loss. J Clin Endocrinol Metab. 2016. doi:10.1210/jc.2016-2726PubMed • PMC full text

Ge R, Wang Z, Bechis SK, et al. DNA methyl transferase 1 reduces expression of SRD5A2 in the aging adult prostate. Am J Pathol. 2015. doi:10.1016/j.ajpath.2014.11.020PubMed • PMC full text

[Commentary] Isaacs JT. Lessons learned about prostatic transformation from the age-related methylation of 5α-reductase type 2 gene. Am J Pathol. 2015 Mar. doi:10.1016/j.ajpath.2015.01.001PubMedPMC full text

Rongbin G, Wang Z, Bechis S, et al. Abstract 1052: Variable expression of 5-alpha reductase 2 in the aging adult prostate is regulated by DNA methylation. Cancer Research. 2015;75(15_Supplement):1052. doi:10.1158/1538-7445.AM2015-1052

Windahl SH, Andersson N, Börjesson AE, et al. Reduced bone mass and muscle strength in male 5α-reductase type 1 inactivated mice. PLoS One. 2011. doi:10.1371/journal.pone.0021402PubMedPMC full text

1995

Berman DM, Tian H, Russell DW. Expression and regulation of steroid 5 alpha-reductase in the urogenital tract of the fetal rat. Mol Endocrinol. 1995. doi:10.1210/mend.9.11.8584033PubMed

“In the adult prostate, 5 alpha-reductase gene expression is under feedforward control, in which the product of the enzyme, dihydrotestosterone, stimulates the expression of the gene.”