Adverse effects in women

Albasher G, Bin-Jumah M, Alfarraj S, et al. Prolonged use of finasteride-induced gonadal sex steroids alterations, DNA damage and menstrual bleeding in women. Biosci Rep. 2020;40(2):BSR20191434. doi:10.1042/BSR20191434PubMed

Fiuk J, Butcher M, Kohler T, McVary K. 133 Female post-finasteride syndrome: it’s not just a man’s world. Journal Sex Med. 2016 May 1;13(5 Suppl 1):S62-S63. doi:10.1016/j.jsxm.2016.02.139

Iamsumang W, Leerunyakul K, Suchonwanit P. Finasteride and its potential for the treatment of female pattern hair loss: evidence to date. Drug Des Devel Ther. 2020 Mar 2;14:951-959. doi:10.2147/DDDT.S240615 | PubMed

Lee SW, Juhasz M, Mobasher P, Ekelem C, Mesinkovska NA. A systematic review of topical finasteride in the treatment of androgenetic alopecia in men and women. J Drugs Dermatol. 2018;17(4):457–463. Journal site | PubMed

Mervis JS, Borda LJ, Miteva M. “Post-finasteride syndrome”: What to tell our female patients? Br J Dermatol. 2018;179(3):785-786. doi:10.1111/bjd.16658 | PubMed

Seale LR, Eglini AN, McMichael AJ. Side effects related to 5 α-reductase inhibitor treatment of hair loss in women: a review. J Drugs Dermatol. 2016;15(4):414-419. Journal site | PubMed

Soares Júnior JM, Guimarães DZ, Simões RDS, et al. Systematic review of finasteride effect in women with hirsutism. Rev Assoc Med Bras (1992). 2021 Jul;67(7):1043-1049. doi:10.1590/1806-9282.20210248 | PubMed

Suchonwanit P, Iamsumang W, Leerunyakul K. Topical finasteride for the treatment of male androgenetic alopecia and female pattern hair loss: a review of the current literature. J Dermatolog Treat. 2020;1-21. doi:10.1080/09546634.2020.1782324 | PubMed

Teichert M, van Puijenbroek E, Stricker BH. Contraindicated use of 5-alpha-reductase inhibitors in women. Br J Clin Pharmacol. 2017;83(2):429-431. doi:10.1111/bcp.13118 | PubMed

Wu M, Yu Q, Li Q. Differences in reproductive toxicology between alopecia drugs: an analysis on adverse events among female and male cases. Oncotarget. 2016;7(50):82074-82084. doi:10.18632/oncotarget.12617 | PubMed

Animal studies

Alkahtane AA, Albasher G, Al-Sultan NK, et al. Long-term treatment with finasteride induces apoptosis and pathological changes in female mice. Hum Exp Toxicol. 2019;38(7):762-774. doi:10.1177/0960327119842195 | PubMed

Cumberland AL, Palliser HK, Crombie GK, Walker DW, Hirst JJ. Increased anxiety-like phenotype in female guinea pigs following reduced neurosteroid exposure in utero. Int J Dev Neurosci. 2017;58:50–58. doi:10.1016/j.ijdevneu.2017.02.001 | PubMed

Erskine MS. Effects of an anti-androgen and 5 alpha-reductase inhibitors on estrus duration in the cycling female rat. Physiol Behav. 1983;30(4):519-524. doi:10.1016/0031-9384(83)90214-7 | PubMed

Frye CA. Inhibition of 5alpha-reductase enzyme or GABA(A) receptors in the VMH and the VTA attenuates progesterone-induced sexual behavior in rats and hamsters. J Endocrinol Invest. 2001 Jun;24(6):399-407. PubMed

Maldarine JS, Sanches BDA, Santos VA, et al. Postnatal exposure to finasteride causes different effects on the prostate of male and female gerbils. Cell Biol Int. 2020 Jun;44(6):1341-1352. doi:10.1002/cbin.11328 | PubMed

Paris JJ, Brunton PJ, Russell JA, Walf AA, Frye CA. Inhibition of 5α-reductase activity in late pregnancy decreases gestational length and fecundity and impairs object memory and central progestogen milieu of juvenile rat offspring. J Neuroendocrinol. 2011;23(11):1079-1090. doi:10.1111/j.1365-2826.2011.02219.x | PubMed