Adverse effects in women

See also: Research on teratogenicity (birth abnormalities)

Textbook chapter

Fierro MC, Yafi FA, Reisman Y. Post-Finasteride Syndrome. In: Reisman Y, Lowenstein L, Tripodi F, eds. Textbook of Rare Sexual Medicine Conditions. Cham: Springer; 2022: 65–79. doi:10.1007/978-3-030-98263-8_6

Original investigation

Albasher G, Bin-Jumah M, Alfarraj S, et al. Prolonged use of finasteride-induced gonadal sex steroids alterations, DNA damage and menstrual bleeding in women. Biosci Rep. 2020. doi:10.1042/BSR20191434 • PubMed

Pharmacovigilance & regulation

Fiuk J, Butcher M, Kohler T, McVary K. 133 Female post-finasteride syndrome: it’s not just a man’s world. Journal Sex Med. 2016 May 1;13(5 Suppl 1):S62-S63. doi:10.1016/j.jsxm.2016.02.139

Teichert M, van Puijenbroek E, Stricker BH. Contraindicated use of 5-alpha-reductase inhibitors in women. Br J Clin Pharmacol. 2017. doi:10.1111/bcp.13118 • PubMed

Wu M, Yu Q, Li Q. Differences in reproductive toxicology between alopecia drugs: an analysis on adverse events among female and male cases. Oncotarget. 2016. doi:10.18632/oncotarget.12617 • PubMed

Research letter

Mervis JS, Borda LJ, Miteva M. “Post-finasteride syndrome”: What to tell our female patients? Br J Dermatol. 2018. doi:10.1111/bjd.16658 • PubMed

Reviews

Iamsumang W, Leerunyakul K, Suchonwanit P. Finasteride and its potential for the treatment of female pattern hair loss: evidence to date. Drug Des Devel Ther. 2020. doi:10.2147/DDDT.S240615 • PubMed

Lee SW, Juhasz M, Mobasher P, Ekelem C, Mesinkovska NA. A systematic review of topical finasteride in the treatment of androgenetic alopecia in men and women. J Drugs Dermatol. 2018. Journal site • PubMed • PMC full text

Nobari NN, Roohaninasab M, Sadeghzadeh-Bazargan A, et al. A systematic review of clinical trials using single or combination therapy of oral or topical finasteride for women in reproductive age and postmenopausal women with hormonal and nonhormonal androgenetic alopecia. Adv Clin Exp Med. 2023. doi:10.17219/acem/157990 • PubMed

Seale LR, Eglini AN, McMichael AJ. Side effects related to 5 α-reductase inhibitor treatment of hair loss in women: a review. J Drugs Dermatol. 2016. Journal site • PubMed

Soares Júnior JM, Guimarães DZ, Simões RDS, et al. Systematic review of finasteride effect in women with hirsutism. Rev Assoc Med Bras (1992). 2021. doi:10.1590/1806-9282.20210248 • PubMed

Suchonwanit P, Iamsumang W, Leerunyakul K. Topical finasteride for the treatment of male androgenetic alopecia and female pattern hair loss: a review of the current literature. J Dermatolog Treat. 2020. doi:10.1080/09546634.2020.1782324 • PubMed

Townsend KA, Marlowe KF. Relative safety and efficacy of finasteride for treatment of hirsutism. Ann Pharmacother. 2004. doi:10.1345/aph.1D461PubMed

Trial

Rokni GR, Mohammadnezhad F, Saeedi M, et al. Efficacy, tolerability, and safety of montelukast versus finasteride for the treatment of moderate acne in women: A prospective, randomized, single-blinded, active-controlled trial. J Cosmet Dermatol. 2021. doi:10.1111/jocd.14462PubMed

See also: Nobari et al, 2023 in Reviews

Animal studies

Alkahtane AA, Albasher G, Al-Sultan NK, et al. Long-term treatment with finasteride induces apoptosis and pathological changes in female mice. Hum Exp Toxicol. 2019. doi:10.1177/0960327119842195 • PubMed

Cumberland AL, Palliser HK, Crombie GK, Walker DW, Hirst JJ. Increased anxiety-like phenotype in female guinea pigs following reduced neurosteroid exposure in utero. Int J Dev Neurosci. 2017. doi:10.1016/j.ijdevneu.2017.02.001 • PubMed

Erskine MS. Effects of an anti-androgen and 5 alpha-reductase inhibitors on estrus duration in the cycling female rat. Physiol Behav. 1983. doi:10.1016/0031-9384(83)90214-7 • PubMed

Maldarine JS, Sanches BDA, Santos VA, et al. Postnatal exposure to finasteride causes different effects on the prostate of male and female gerbils. Cell Biol Int. 2020. doi:10.1002/cbin.11328 • PubMed

Paris JJ, Brunton PJ, Russell JA, Walf AA, Frye CA. Inhibition of 5α-reductase activity in late pregnancy decreases gestational length and fecundity and impairs object memory and central progestogen milieu of juvenile rat offspring. J Neuroendocrinol. 2011. doi:10.1111/j.1365-2826.2011.02219.x • PubMed