Serenoa repens (saw palmetto) and other natural 5-AR inhibitors


Srivilai J, Minale G, Scholfield CN, Ingkaninan K. Discovery of natural steroid 5 alpha-reductase inhibitors. Assay Drug Dev Technol. 2019 Feb/Mar. doi:10.1089/adt.2018.870 • PubMed

Serenoa repens (saw palmetto)

Abd Almaksoud HM, El-Hawary SS, Atia MAM, et al. Anti-androgenic potential of the fruit extracts of certain Egyptian Sabal species and their genetic variability studies: a metabolomic-molecular modeling approach. Food Funct. 2022 Jun 29. doi:10.1039/d1fo03930j • PubMed

Abe M, Ito Y, Suzuki A, Onoue S, Noguchi H, Yamada S. Isolation and pharmacological characterization of fatty acids from saw palmetto extract. Anal Sci. 2009 Apr;25(4):553-7. doi:10.2116/analsci.25.553 • PubMed

Agbabiaka TB, Pittler MH, Wider B, Ernst E. Serenoa repens (saw palmetto): a systematic review of adverse events. Drug Saf. 2009. doi:10.2165/00002018-200932080-00003 • PubMed

Alcaraz A, Castro-Díaz D, Gacci M, […], on behalf of the Qualiprost Study Group. Efficacy and tolerability of 6-month treatment with tamsulosin plus the hexanic extract of Serenoa repens versus tamsulosin plus 5-alpha-reductase inhibitors for moderate-to-severe LUTS-BPG patients: results of a paired matched clinical study. J Clin Med. 2022 Jun 22. doi:10.3390/jcm11133615 • PubMed • PMC full text

Avins AL, Bent S, Staccone S, et al. A detailed safety assessment of a saw palmetto extract. Complement Ther Med. 2008 Jun. doi:10.1016/j.ctim.2007.10.005 • PubMed • PMC full text

Avins AL, Lee JY, Meyers CM, Barry MJ; CAMUS Study Group. Safety and toxicity of saw palmetto in the CAMUS trial. J Urol. 2013 Apr. doi:10.1016/j.juro.2012.10.002 • PubMed • PMC full text

Committee on Herbal Medicinal Products (HMPC), European Medicines Agency. Assessment report on Serenoa repens (W. Bartram) Small, fructus. November 24, 2015.

Gallo E, Maggini V, Lombardi N, et al. Serenoa repens induced erectile dysfunction: Underdiagnosis and phytovigilance. Br J Clin Pharmacol. 2021 Nov 7. doi:10.1111/bcp.15129 • PubMed

Gammoudi R, Ameur K, Ouni B, et al. Fixed drug eruption to Serenoa repens: First case report and consideration of the use of herbal medicine. Dermatol Ther. 2020 Nov. doi:10.1111/dth.14247 • PubMed

National Center for Complementary and Integrative Health (NCCIH), United States Department of Health and Human Services. Saw Palmetto.

Pais P, Villar A, Rull S. Determination of the potency of a novel saw palmetto supercritical CO2 extract (SPSE) for 5α-reductase isoform II inhibition using a cell-free in vitro test system. Res Rep Urol. 2016 Apr 21. doi:10.2147/RRU.S96576 • PubMed • PMC full text

Paulis G, Paulis A, Perletti G. Serenoa repens and its effects on male sexual function. A systematic review and meta-analysis of clinical trials. Arch Ital Urol Androl. 2021 Dec. doi:10.4081/aiua.2021.4.475 • PubMed

Sinclair RD, Mallari RS, Tate B. Sensitization to saw palmetto and minoxidil in separate topical extemporaneous treatments for androgenetic alopecia. Australas J Dermatol. 2002 Nov. doi:10.1046/j.1440-0960.2002.00620.x • PubMed

Yeu E, Grostern R. Saw palmetto and intraoperative floppy-iris syndrome. J Cataract Refract Surg. 2007 May. doi:10.1016/j.jcrs.2006.12.032 • PubMed