Vascular system & stroke

Retrospective studies

Ayodele O, Cabral HJ, McManus D, Jick S. The risk of venous thromboembolism (VTE) in men with benign prostatic hyperplasia treated with 5-alpha reductase inhibitors (5ARIs). Clin Epidemiol. 2021 Aug 3. doi:10.2147/CLEP.S317019 • PubMed • PMC full text

Loke YK, Ho R, Smith M, et al. Systematic review evaluating cardiovascular events of the 5-alpha reductase inhibitor – dutasteride. J Clin Pharm Ther. 2013 Oct;38(5):405-15. doi:10.1111/jcpt.12080 • PubMed

[⚠️ Funded by Yamanouchi Europe] Souverein PC, Herings RM, Man in ‘t Veld AJ, de la Rosette JJ, Farmer RD, Leufkens HG. Study of the association between ischemic heart disease and use of alpha-blockers and finasteride indicated for the treatment of benign prostatic hyperplasia. Eur Urol. 2002 Sep. doi:10.1016/s0302-2838(02)00273-7PubMed


Traish AM, Guay AT, Zitzmann M. 5α-reductase inhibitors alter steroid metabolism and may contribute to insulin resistance, diabetes, metabolic syndrome and vascular disease: a medical hypothesis. Horm Mol Biol Clin Investig. 2014. doi:10.1515/hmbci-2014-0025 • PubMed

Case reports

Choi BK, Cheon K, Cho BH, Jung JW, Lee KY. Cerebral venous sinus thrombosis associated with dutasteride use. Yonsei Med J. 2020. doi:10.3349/ymj.2020.61.6.553 • PubMed • PMC full text

Chou CH, Lin CL, Lin MC, Sung FC, Kao CH. 5α-reductase inhibitors increase acute coronary syndrome risk in patients with benign prostate hyperplasia. J Endocrinol Invest. 2015. doi:10.1007/s40618-015-0263-1PubMed

Kang DW, Jeong HG, Kim HR, et al. Finasteride induced cerebral venous thrombosis. Journal of the Korean Neurological Association. 2015;33(3):238-240. PDF at ResearchGate

Kuno T, Uchida Y, Usami T, et al. A young male of [sic] hemorrhagic cerebral infarction associated with finasteride and minoxidil. Nosotchu. 2020;42(4):244-247. Japanese. doi:10.3995/jstroke.10722 • ResearchGate • Automated translation to English (unofficial)

Lear JT, Byrne JP. Finasteride-related cutaneous vasculitis. Postgraduate Medical Journal 1996;72:127. doi:10.1136/pgmj.72.844.127-a • PubMedPMC full text

Tsuji Y, Nakayama T, Bono K, Kitamura M, Imafuku I. [Two cases of stroke associated with the use of finasteride, an approved drug for male-pattern hair loss in Japan]. Rinsho Shinkeigaku. 2014;54(5):423-8. Japanese. doi:10.5692/clinicalneurol.54.423 • PubMed