Dihydrotestosterone – biochemistry & physiology

See also: Research on 5-alpha reductase enzyme & expression

General

Anawalt BD. Is dihydrotestosterone a classic hormone? Endocr Rev. 2017. doi:10.1210/er.2017-00091PubMed

Marchetti PM, Barth JH. Clinical biochemistry of dihydrotestosterone. Ann Clin Biochem. 2013. doi:10.1258/acb.2012.012159PubMed

Fukami M, Homma K, Hasegawa T, Ogata T. Backdoor pathway for dihydrotestosterone biosynthesis: implications for normal and abnormal human sex development. Dev Dyn. 2013. doi:10.1002/dvdy.23892 • PubMed

Swerdloff RS, Dudley RE, Page ST, Wang C, Salameh WA. Dihydrotestosterone: biochemistry, physiology, and clinical implications of elevated blood levels. Endocr Rev. 2017. doi:10.1210/er.2016-1067PubMedPMC full text

Eyes

Sahin A, Liu Y, Kam WR, Darabad RR, Sullivan DA. Dihydrotestosterone suppression of proinflammatory gene expression in human meibomian gland epithelial cells. Ocul Surf. 2020. doi:10.1016/j.jtos.2020.02.006 • PubMedPMC full text

Gums

Southren AL, Rappaport SC, Gordon GG, Vittek J. Specific 5 alpha-dihydrotestosterone receptors in human gingiva. J Clin Endocrinol Metab. 1978. doi:10.1210/jcem-47-6-1378 • PubMed

Pituitary

Magri ML, Gottardo MF, Zárate S, et al. Opposite effects of dihydrotestosterone and estradiol on apoptosis in the anterior pituitary gland from male rats. Endocrine. 2016. doi:10.1007/s12020-015-0719-2 • PubMed

Prostate

Bartsch G, Rittmaster RS 💊 [COIs], Klocker H. Dihydrotestosterone and the concept of 5alpha-reductase inhibition in human benign prostatic hyperplasia. World J Urol. 2002. doi:10.1007/s00345-002-0248-5 • PubMed

Sexuality

💊 [Supported by grant from Merck] Lugg JA, Rajfer J, González-Cadavid NF. Dihydrotestosterone is the active androgen in the maintenance of nitric oxide-mediated penile erection in the rat. Endocrinology. 1995. doi:10.1210/endo.136.4.7534702PubMed

Mantzoros CS, Georgiadis EI, Trichopoulos D. Contribution of dihydrotestosterone to male sexual behaviour. BMJ. 1995. doi:10.1136/bmj.310.6990.1289PubMed • PMC full text

Sansone A, Kliesch S, Dugas M, et al. Serum concentrations of dihydrotestosterone are associated with symptoms of hypogonadism in biochemically eugonadal men. J Endocrinol Invest. 2021. doi:10.1007/s40618-021-01561-0PubMedPMC full text

Sasaki G, Ishii T, Hori N, Amano N, Homma K, Sato S, Hasegawa T. Effects of pre- and post-pubertal dihydrotestosterone treatment on penile length in 5α-reductase type 2 deficiency. Endocr J. 2019. doi:10.1507/endocrj.EJ19-0111PubMed

Vascular function

Gonzales RJ, Ansar S, Duckles SP, Krause DN. Androgenic/estrogenic balance in the male rat cerebral circulation: metabolic enzymes and sex steroid receptors. J Cereb Blood Flow Metab. 2007. doi:10.1038/sj.jcbfm.9600483 • PubMedPMC full text

Koukoulis GN, Filiponi M, Gougoura S, Befani C, Liakos P, Bargiota Α. Testosterone and dihydrotestosterone modulate the redox homeostasis of endothelium. Cell Biol Int. 2022 Apr. doi:10.1002/cbin.11768 • PubMed