Epigenetics of adverse drug reactions

See also: Isotretinoin

Becker E, Bengs S, Aluri S, et al. Large-scale integrative analysis of epigenetic modifications induced by isotretinoin, doxycycline and metronidazole in murine colonic intestinal epithelial cells. Epigenomes. 2017. doi:10.3390/epigenomes1030024

Csoka AB, El Kouhen N, Bennani S, Getachew B, Aschner M, Tizabi Y. Roles of epigenetics and glial cells in drug-induced autism spectrum disorder. Biomolecules. 2024. doi:10.3390/biom14040437PubMed • PMC full text

Csoka AB, Szyf M. Epigenetic side-effects of common pharmaceuticals: a potential new field in medicine and pharmacology. Med Hypotheses. 2009 Nov. doi:10.1016/j.mehy.2008.10.039PubMed

Eckstein M, Rea M, Fondufe-Mittendorf YN. Transient and permanent changes in DNA methylation patterns in inorganic arsenic-mediated epithelial-to-mesenchymal transition. Toxicol Appl Pharmacol. 2017 Sep 15. doi:10.1016/j.taap.2017.03.017 • PubMed • PMC full text

Fisel P, Schaeffeler E, Schwab M. DNA methylation of ADME genes. Clin Pharmacol Ther. 2016. doi:10.1002/cpt.343PubMed

Heller E, Cates H, Peña C, et al. Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors. Nat Neurosci. 2014. doi:10.1038/nn.3871

Jiang Y, Chen H, Han L, Xie X, Zheng Y, Lai W. Altered gene expression in acne vulgaris patients treated by oral isotretinoin: a preliminary study. Pharmgenomics Pers Med. 2020 Sep 15. doi:10.2147/PGPM.S250969PubMedPMC full text

Kacevska M, Ivanov M, Ingelman-Sundberg M. Perspectives on epigenetics and its relevance to adverse drug reactions. Clin Pharmacol Ther. 2011. doi:10.1038/clpt.2011.21PubMed

Kanherkar RR, Getachew B, Ben-Sheetrit J, et al. The effect of citalopram on genome-wide DNA methylation of human cells. Int J Genomics. 2018 Jul 25. doi:10.1155/2018/8929057PubMedPMC full text

Nelson AM, Zhao W, Gilliland KL, Zaenglein AL, Liu W, Thiboutot DM. Early gene changes induced by isotretinoin in the skin provide clues to its mechanism of action. Dermatoendocrinol. 2009 Mar. doi:10.4161/derm.1.2.8107PubMedPMC full text

Nelson AM, Zhao W, Gilliland KL, Zaenglein AL, Liu W, Thiboutot DM. Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May. doi:10.4161/derm.1.3.8258 • PubMed • PMC full text

Toth M. Epigenetic neuropharmacology: drugs affecting the epigenome in the brain. Annu Rev Pharmacol Toxicol. 2021. doi:10.1146/annurev-pharmtox-030220-022920 • PubMed