Animal studies

Research review: Alterations to penile and prostatic tissue associated with finasteride and dutasteride treatment

July 21, 2023November 11, 2021 by Montaigne

Numerous studies have shown that treatment with finasteride and dutasteride can change the size, tissue composition and function of the penis and prostate. Changes to the penis include: reduced size and weight; reduced erectile response; decreased smooth muscle; increased collagen density; and fibrosis (scarring).

Study finds changes in rats’ brain signaling after discontinuation of paroxetine, an SSRI

August 27, 2022August 27, 2021 by Montaigne

Even 30 days after stopping paroxetine, the treatment group had significant differences in neuroactive steroids and associated enzymes, in brain areas which help govern emotion, behavior and sexuality.