Context matters: a rebuttal to yet another analysis of adverse events of finasteride

This post responds to a recent research letter: Nguyen DD, et al. Disproportional signal of sexual dysfunction reports associated with finasteride use in young men with androgenetic alopecia: A pharmacovigilance analysis of VigiBase. J Am Acad Dermatol. 2022. doi:10.1016/j.jaad.2022.03.037 A recent paper by Nguyen et al. in the Journal of the American Academy of Dermatology analyzes sexual adverse … Read more

A tweeted rebuttal to yet another analysis of finasteride adverse events: Nguyen et al, 2022

An expanded version of this rebuttal is here: Context matters: a rebuttal to yet another analysis of adverse events of finasteride A thread originally posted on Twitter is reproduced below, with bolding added for easier scanning. See also: a critique of three previous papers with similar designs, findings and conclusions. Twitter thread Nguyen et al, … Read more

Merck communications regarding reports of persistent erectile dysfunction and depression associated with finasteride

See also: The Merck files: a series In regulatory, internal and media communications in the 2000s, Merck responded to concerns about reports of adverse events associated with Propecia, including persistent erectile dysfunction and depression. These documents seek to discount the validity of these reports by way of the following points: “insufficient” information including lack of … Read more

Responding to a literature of doubt: limitations of three studies of adverse events of finasteride and dutasteride

A fourth study has been published in the ‘literature of doubt’. Read the rebuttal. Background on the co-author of Baas et al, 2018 with a disclosed conflict of interest is here. Three studies analyzing adverse event (AE) data related to finasteride and dutasteride were published from 2018–2020 (the “AE papers”).1–3 The first to appear, by Baas … Read more

Adverse events affecting reproductive anatomy and sexual function in younger men who took finasteride

Summary This post documents adverse events (AEs) of finasteride affecting male reproductive anatomy and sexual function in men age 18–40, which were reported to US FDA and downloaded from the Federal Adverse Event Reporting System Public Dashboard. The data range is January 1, 2000 to December 31, 2020. This shows AEs assigned to categories which … Read more